Association between cystatin C gene polymorphism and the prevalence of white matter lesion in elderly healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61383-7
Abstract: Cystatin C (CST3) is a cysteine protease inhibitor abundant in the central nervous system, and demonstrated to have roles in several pathophysiological processes including vascular remodeling and inflammation. Previously, we showed a relation of CST3… read more here.
Keywords: carriers minor; allele haplotype; minor allele; gene ... See more keywords
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13730
Abstract: Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or… read more here.
Keywords: survival older; tomm40; carriers minor; older ages ... See more keywords