Abstract 1153: IL-4 depletion leads to the improvement of CART cell therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1153
Abstract: While chimeric antigen receptor T-cell therapy targeting CD19 (CART19) has shown remarkable success in the treatment of hematological malignancies, the durable response rates remain approximately 40% and there are limited solutions for CART cell therapy… read more here.
Keywords: cell therapy; cell; cart cell; cart19 ... See more keywords
CART Cell Therapy Targeting CD84 Alone or in Combination with CD19 for the Treatment of B-Cell Malignancies
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DOI: 10.1182/blood-2024-207309
Abstract: Most B-cell acute lymphoblastic leukemia (B-ALL) patients (>70%) and B-cell lymphoma patients (>50%) achieve complete remission with CD19-directed CART cell therapy (CART19). However, leukemic cells that either lack or have low levels of CD19 expression… read more here.
Keywords: cell; cd19 cd84; cart cell; cart ... See more keywords
Remodeling the bone marrow tumor microenvironment with CART cell therapy to overcome resistance in multiple myeloma
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DOI: 10.1182/blood-2025-1028
Abstract: B cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (CART) cell therapies have emerged as a potentially curative treatment for multiple myeloma (MM). However, 50-70% of patients relapse within 3 years. The MM tumor microenvironment… read more here.
Keywords: cart cells; bcma cart; cart cell; cart ... See more keywords
Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma.
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DOI: 10.1182/blood.2021012811
Abstract: Pivotal clinical trials of B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed/refractory multiple myeloma (MM) resulted in remarkable initial responses, which led to a recent FDA approval. Despite their… read more here.
Keywords: cell; cart cell; cell therapy; multiple myeloma ... See more keywords