Development of a Sensitive and Efficient Reporter Platform for the Detection of Chimeric Antigen Receptor T Cell Expansion, Trafficking, and Toxicity
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.450
Abstract: Introduction Despite the success of chimeric antigen receptor T (CART) cell therapy, it is limited by lower rates of durable responses related to inadequate CART cell expansion and trafficking and life-threatening complications such as cytokine… read more here.
Keywords: cart; expansion trafficking; cart cells; cell expansion ... See more keywords
Co-expression of an engineered cell-surface sialidase by CART cells improves anti-cancer activity of NK cells in solid tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.338
Abstract: Background & Aim Clinical success of CART cells targeting CD19 has led to FDA approval for a wide-range of hematological malignancies. Despite these achievements, CARs have lacked efficacy in the treatment of solid tumors due… read more here.
Keywords: cancer; activity; cart cells; cell ... See more keywords
Long-term safety and efficacy of CART-20 cells in patients with refractory or relapsed B-cell non-Hodgkin lymphoma: 5-years follow-up results of the phase I and IIa trials
Sign Up to like & getrecommendations! Published in 2017 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/sigtrans.2017.54
Abstract: Long-term safety and efficacy of CART-20 cells in patients with refractory or relapsed B-cell non-Hodgkin lymphoma: 5-years follow-up results of the phase I and IIa trials read more here.
Keywords: cart cells; long term; safety efficacy; efficacy cart ... See more keywords
Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835920927605
Abstract: Autologous CD19-targeted chimeric antigen receptor-modified T cells (CD19-CART) remarkably improved the outcome of patients with advanced B-cell acute lymphoblastic leukemia (B-ALL). However, the application and outcomes of allogeneic CART cells is still uncertain. Two patients… read more here.
Keywords: cart cells; cd19 targeted; high dose; donor ... See more keywords
Targeting Cancer Associated Fibroblasts in the Bone Marrow Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123277
Abstract: Cellular immunotherapy is a rapidly progressing field in multiple myeloma (MM). Multiple clinical trials have reported impressive efficacy of B cell maturation antigen (BCMA) directed chimeric antigen receptor cell therapy (BCMA CART) in MM. While… read more here.
Keywords: cart; cell; cart cells; research funding ... See more keywords
Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy
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DOI: 10.1182/blood-2020-141115
Abstract: Chimeric antigen receptor T (CART) cells are engineered with an artificial receptor which redirects T cells to recognize cancer cells expressing a particular surface antigen. CART cell therapy has been astonishingly successful at eradicating certain… read more here.
Keywords: cart19; cas9; research funding; cart cells ... See more keywords
Engineered T lymphocytes eliminate lung metastases in models of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24122
Abstract: Pancreatic cancer is known as one of the most lethal cancers in the world. A majority of advanced stage pancreatic cancer patients are diagnosed with distant metastasis and given poor prognoses, calling for a better… read more here.
Keywords: cart cells; lung metastases; meso cart; pancreatic cancer ... See more keywords