Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1680-3
Abstract: Osteoarthritis (OA), the most common form of arthritis, is characterized by inflammation of joints and cartilage degradation leading to disability, discomfort, severe pain, inflammation, and stiffness of the joint. It has been shown that adenosine,… read more here.
Keywords: ablation; adenosine receptor; articular cartilage; cartilage degeneration ... See more keywords
Differentiation of human cartilage degeneration by functional MRI mapping—an ex vivo study
Sign Up to like & getrecommendations! Published in 2019 at "European Radiology"
DOI: 10.1007/s00330-019-06283-9
Abstract: ObjectiveTo evaluate whether the response to loading of cartilage samples as assessed ex vivo by quantitative MRI (qMRI) mapping techniques can differentiate intact and early degenerative cartilage.MethodsUpon IRB approval and written informed consent, 59 macroscopically… read more here.
Keywords: functional mri; cartilage degeneration; cartilage; early degenerative ... See more keywords
Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-018-02184-y
Abstract: Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to… read more here.
Keywords: knee joint; based modeling; cartilage degeneration; degeneration ... See more keywords
Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase‐1 in human articular chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.018
Abstract: Abstract Osteoarthritis (OA) is common age‐associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease.… read more here.
Keywords: cartilage degeneration; heme oxygenase; articular chondrocytes; human articular ... See more keywords
Spectrum of common and uncommon causes of knee joint hyaline cartilage degeneration and their key imaging features.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2020.109097
Abstract: Hyaline cartilage lining the surfaces of diarthrodial joints is an important construct for transmission of load and to reduce friction between the bones. Normal wear and tear accounts for about 3-5 percent knee cartilage loss… read more here.
Keywords: hyaline cartilage; key imaging; imaging features; cartilage degeneration ... See more keywords
Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102643
Abstract: Summary Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA. In this study, we analyzed the molecular response of chondrocytes… read more here.
Keywords: flightless catabolic; catabolic factor; cartilage degeneration; factor chondrocytes ... See more keywords
Cartilage Degeneration of the Metacarpal Condyle and Enthesopaties of The Collateral Ligaments of Equine Metacarpophalangeal Joint.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2021.103754
Abstract: Articular degeneration can be characterized by fibrillation and eburnation of the articular layers of the metacarpophalangeal (MP) joint. Structural changes within the articular joint predispose the development of osteophytes, enthesophytes and, in many cases is… read more here.
Keywords: cartilage degeneration; joint; collateral ligaments; metacarpophalangeal joint ... See more keywords
Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2016.09.002
Abstract: OBJECTIVE The purpose of this study was to determine if serum microRNA (miRNA) signatures were biomarkers of early cartilage degeneration in preclinical mouse models of post-traumatic osteoarthritis (OA) and inflammatory arthritis. METHODS Cartilage degeneration was… read more here.
Keywords: cartilage degeneration; arthritis; serum mirnas; cartilage ... See more keywords
Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.12.014
Abstract: OBJECTIVE We have reported that fibrotic changes in infrapatellar fat pad (IFP) after acute joint inflammation are closely associated with persistent pain in rats. In this study, to examine the effects of anti-fibrotic treatment on… read more here.
Keywords: fibrotic changes; persistent pain; articular cartilage; cartilage degeneration ... See more keywords
Effects of repeated intra-articular hyaluronic acid on cartilage degeneration evaluated by T1ρ mapping in knee osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Modern Rheumatology"
DOI: 10.1080/14397595.2020.1830483
Abstract: Abstract Objectives Intra-articular injection of hyaluronic acid (IAHA) has been used for the treatment of knee osteoarthritis (OA), but its effectiveness remains controversial. This study analyzed knee OA over time by magnetic resonance imaging (MRI)… read more here.
Keywords: cartilage degeneration; hyaluronic acid; knee; intra articular ... See more keywords
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13662
Abstract: Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint… read more here.
Keywords: health; mitochondrial health; mitophagy mitochondrial; cartilage degeneration ... See more keywords