A Novel Multiplex Based Platform for Osteoarthritis Drug Candidate Evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-020-02539-4
Abstract: Osteoarthritis (OA) is characterized by irreversible cartilage degradation with very limited therapeutic interventions. Drug candidates targeted at prototypic players had limited success until now and systems based approaches might be necessary. Consequently, drug evaluation platforms… read more here.
Keywords: drug; evaluation; candidate; cartilage degradation ... See more keywords
Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.059
Abstract: The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat… read more here.
Keywords: sasp; sulfasalazine containing; inflammation; cartilage degradation ... See more keywords
Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.07.003
Abstract: Osteoarthritis (OA) is a chronic and degenerative disease that causes pain, cartilage deformation, and joint inflammation. Lactobacillus species have been used as dietary supplements to induce the production of antimicrobial and anti-inflammatory factors. The goal… read more here.
Keywords: acidophilus ameliorates; ameliorates pain; osteoarthritis; lactobacillus acidophilus ... See more keywords
MicroRNA-27a alleviates IL-1β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105839
Abstract: Osteoarthritis (OA) is a common disease of the articular cartilage, and inflammatory response and articular cartilage degradation have been implicated in the pathogenesis of OA. In recent years, microRNAs (miRNAs) have been potentially involved in… read more here.
Keywords: mir 27a; inflammatory response; articular cartilage; cartilage degradation ... See more keywords
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.12.004
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Osteoarthritis (OA), characterized by joint pain and cartilage degradation, is the most common form of joint disease worldwide but with no satisfactory therapy available. The ethanol extract of Agkistrodon acutus (EAA) has been… read more here.
Keywords: apoptosis; chondrocyte hypertrophy; hypertrophy apoptosis; cartilage degradation ... See more keywords
Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.10.011
Abstract: OBJECTIVE Lumican (LUM) is a major extracellular matrix glycoprotein in adult articular cartilage and its expression is known to be upregulated upon cartilage degeneration. LUM is associated with the pathogen-associated molecular pattern (PAMP) activation of… read more here.
Keywords: lum; activation; cartilage degradation; pro inflammatory ... See more keywords
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition"
DOI: 10.1016/j.nut.2016.08.004
Abstract: OBJECTIVE Osteoarthritis (OA) is characterized by cartilage degradation in the affected joints. Pomegranate fruit extract (PFE) inhibits cartilage degradation in vitro. The aim of this study was to determine whether oral consumption of PFE inhibits disease… read more here.
Keywords: osteoarthritis; mmp; expression; pfe ... See more keywords
No effect of creatine monohydrate supplementation on inflammatory and cartilage degradation biomarkers in individuals with knee osteoarthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition research"
DOI: 10.1016/j.nutres.2017.12.010
Abstract: The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis… read more here.
Keywords: supplementation; knee osteoarthritis; creatine monohydrate; cartilage degradation ... See more keywords
Radical-Scavenging and Subchondral Bone-Regenerating Nanomedicine for Osteoarthritis Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01789
Abstract: Osteoarthritis (OA) is characterized by cartilage degradation and subchondral bone remodeling. However, most available studies focus on either cartilage degradation or subchondral bone lesion, alone, and rarely pay attention to the synergy of these two… read more here.
Keywords: bone; cartilage degradation; osteoarthritis; treatment ... See more keywords
Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45334-5
Abstract: CHUK/IKKα contributes to collagenase-driven extracellular matrix remodeling and chondrocyte hypertrophic differentiation in vitro, in a kinase-independent manner. These processes contribute to osteoarthritis (OA), where chondrocytes experience a phenotypic shift towards hypertrophy concomitant with abnormal matrix… read more here.
Keywords: chuk ikk; ikk; adult chondrocytes; cartilage degradation ... See more keywords
Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Food and Agricultural Immunology"
DOI: 10.1080/09540105.2019.1611745
Abstract: ABSTRACT Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity. Soya-cerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine… read more here.
Keywords: soya cerebroside; degradation; production; cartilage degradation ... See more keywords