Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18208-y
Abstract: Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our… read more here.
Keywords: apoptosis; articular cartilage; cartilage destruction; receptor ... See more keywords
IL-6, IL-1β and TNF-α regulation of the chondrocyte phenotype: a possible mechanism of haemophilic cartilage destruction.
Sign Up to like & getrecommendations! Published in 2023 at "Hematology"
DOI: 10.1080/16078454.2023.2179867
Abstract: OBJECTIVE Proinflammatory cytokines are considered to be one of the key causes of haemophilic cartilage destruction by inducing chondrocyte apoptosis and extracellular matrix degradation. However, few studies have focused on how proinflammatory cytokines regulate the… read more here.
Keywords: cartilage destruction; tnf; haemophilic cartilage; cartilage ... See more keywords
Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells International"
DOI: 10.1155/2021/2989054
Abstract: Osteoarthritis (OA), the most common type of arthritis, causes pain in joints and disability. Due to the absence of ideal effective medication, stem cell transplantation emerges as a new hope for OA therapy. This study… read more here.
Keywords: mesenchymal stromal; model; cartilage destruction; transplantation ... See more keywords
Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death
Sign Up to like & getrecommendations! Published in 2022 at "Immune Network"
DOI: 10.4110/in.2022.22.e34
Abstract: Osteoarthritis (OA) is the most common form of arthritis associated with ageing. Vitamin D has diverse biological effect on bone and cartilage, and observational studies have suggested it potential benefit in OA progression and inflammation… read more here.
Keywords: cell death; cartilage destruction; inflammatory cell; cartilage ... See more keywords