Mandible Explant Assay for the Analysis of Meckel's Cartilage Development.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1847-9_16
Abstract: Ex vivo explant models are a valuable tool for analyzing organ and tissue morphogenesis, providing the opportunity to manipulate and interrogate specific cellular and/or molecular pathways that may not be possible using conventional methods in… read more here.
Keywords: development; culture; mandible explant; cartilage ... See more keywords
Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on fetal articular cartilage development.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.01.008
Abstract: Dexamethasone, a synthetic long-acting glucocorticoid, is routinely used for treating mothers at risk for preterm delivery. However, intrauterine overexposure to glucocorticoids induces low birth weight and cartilage dysplasia in offspring. Also, the "critical window" and… read more here.
Keywords: articular cartilage; toxic effects; cartilage development; stage ... See more keywords
Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a/beta-catenin pathway during chondrocranial cartilage development.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.08.004
Abstract: The mammalian skull is composed of the calvarial bones and cartilages. Malformation of craniofacial cartilage has been identified in multiple human syndromes. However, the mechanisms of their development remain largely unknown. In the present study,… read more here.
Keywords: pdgfra; chondrocranial cartilage; differentiation; cartilage development ... See more keywords
CHD7 regulates craniofacial cartilage development via controlling HTR2B expression
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bone and Mineral Research"
DOI: 10.1093/jbmr/zjae024
Abstract: Abstract Mutations in the Chromodomain helicase DNA-binding protein 7 – coding gene (CHD7) cause CHARGE syndrome (CS). Although craniofacial and skeletal abnormalities are major features of CS patients, the role of CHD7 in bone and… read more here.
Keywords: cartilage development; craniofacial cartilage; cartilage; chd7 ... See more keywords
Primary cilia: Versatile regulator in cartilage development
Sign Up to like & getrecommendations! Published in 2020 at "Cell Proliferation"
DOI: 10.1111/cpr.12765
Abstract: Cartilage is a connective tissue in the skeletal system and has limited regeneration ability and unique biomechanical reactivity. The growth and development of cartilage can be affected by different physical, chemical and biological factors, such… read more here.
Keywords: signalling transduction; cilia versatile; primary cilia; cartilage development ... See more keywords
Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation
Sign Up to like & getrecommendations! Published in 2024 at "Cell Proliferation"
DOI: 10.1111/cpr.13691
Abstract: The regulatory mechanisms involved in embryonic development are complex and yet remain unclear. SCP4 represents a novel nucleus‐resident phosphatase identified in our previous study. The primary aim of this study was to elucidate the function… read more here.
Keywords: scp4; development; cartilage development; endochondral osteogenesis ... See more keywords
Quantification and comparison of teleost scleral cartilage development and growth
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Anatomy"
DOI: 10.1111/joa.13727
Abstract: The ocular skeleton is composed of the scleral cartilage and the scleral ossicles. Teleost scleral cartilage is composed of a single layer of chondrocytes embedded in the sclera of the eye. The teleost scleral cartilage… read more here.
Keywords: teleost scleral; growth; cartilage; scleral cartilage ... See more keywords
Lactate inhibits mouse embryonic palatal mesenchyme cells chondrogenesis through AKT-PKM2 axis
Sign Up to like & getrecommendations! Published in 2025 at "BMC Oral Health"
DOI: 10.1186/s12903-025-06632-9
Abstract: The development of the palate is a complex and continuous process, occurring in a series of stages with cartilage of being particular significance. Chondrogenesis is influenced by many factors such as metabolism, and hypoxia which… read more here.
Keywords: cartilage development; lactate; cartilage; palatal cartilage ... See more keywords
Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229449
Abstract: Anterior cruciate ligament (ACL) transection surgery in the minipig induces post-traumatic osteoarthritis (PTOA) in a pattern similar to that seen in human patients after ACL injury. Prior studies have reported the presence of cartilage matrix-degrading… read more here.
Keywords: proteolysis; synovium; acl transection; cartilage development ... See more keywords
Cartilage organoids for cartilage development and cartilage-associated disease modeling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1125405
Abstract: Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases. Recent breakthroughs have uncovered “mini-joint” models comprising of multicellular components and… read more here.
Keywords: cartilage associated; disease; cartilage; cartilage organoids ... See more keywords