The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120555
Abstract: Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide. However, the current pharmacological approaches used to treat OA are largely palliative. Being the hallmark of OA, the cartilage extracellular matrix (ECM) destruction… read more here.
Keywords: homeostasis; cartilage extracellular; extracellular matrix; joint cartilage ... See more keywords
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14173
Abstract: Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the… read more here.
Keywords: cartilage extracellular; proteinases turnover; turnover cartilage; extracellular matrix ... See more keywords
DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9468040
Abstract: Osteoarthritis (OA) has been reported as a progressive disease in the elderly, primarily characterized by degenerated articular cartilage. There has been no satisfactory drug for the treatment of OA. DL-3-n-butylphthalide (NBP), a small molecule compound… read more here.
Keywords: extracellular matrix; cartilage extracellular; promotes cartilage; osteoarthritis development ... See more keywords
Outcomes Following Treatment of Talar Osteochondral Lesions with a Mixture of Particulate Allogenic Cartilage Extracellular Matrix and Bone Marrow Aspirate Concentrate: A Case Control Series
Sign Up to like & getrecommendations! Published in 2019 at "Orthopaedic Journal of Sports Medicine"
DOI: 10.1177/2325967119s00324
Abstract: Objectives: There continues to be a general lack of consensus regarding the optimal treatment for osteochondral lesions of the talus (OLTs). Microfracture, once considered the gold-standard, has been associated with poor long-term results due to… read more here.
Keywords: treatment; microfracture; cartilage extracellular; cartilage ... See more keywords
Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-β3 for chondrogenic differentiation of adipose-derived stem cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s141888
Abstract: A 3-D scaffold that simulates the microenvironment in vivo for regenerating cartilage is ideal. In this study, we combined silk fibroin and decellularized cartilage extracellular matrix by temperature gradient-guided thermal-induced phase separation to produce composite… read more here.
Keywords: cartilage extracellular; silk fibroin; tgf; chondrogenic differentiation ... See more keywords
The effect of cartilage extracellular matrix particle size on the chondrogenic differentiation of bone marrow mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Regenerative medicine"
DOI: 10.2217/rme-2018-0082
Abstract: Aim: To investigate the effect of cartilage extracellular matrix (ECM) particle size on the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Materials & methods: BMSCs were seeded into the scaffolds fabricated by small… read more here.
Keywords: effect cartilage; cartilage extracellular; extracellular matrix; particle ... See more keywords