Serum cartilage oligomeric matrix protein as a biomarker for predicting development and progression of knee osteoarthritis
Sign Up to like & getrecommendations! Published in 2021 at "International Orthopaedics"
DOI: 10.1007/s00264-021-04943-4
Abstract: Current modes of diagnosing and monitoring knee osteoarthritis (OA) are based on weight bearing radiographs usually made by the time joint destruction is already established. Cartilage oligomeric matrix protein (COMP) is a breakdown product of… read more here.
Keywords: matrix protein; cartilage oligomeric; knee osteoarthritis; oligomeric matrix ... See more keywords
Cartilage oligomeric matrix protein is an endogenous Ī²-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury
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DOI: 10.1038/s41422-020-00464-8
Abstract: Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeostasis and injury, but whether a clinically relevant… read more here.
Keywords: matrix protein; cartilage oligomeric; at1 receptor; at1 ... See more keywords
Elevated serum cartilage oligomeric matrix protein and the metalloproteinaseāADAMTS7 levels are associated with vascular calcification in maintenance hemodialysis patients
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DOI: 10.1111/sdi.12885
Abstract: Vascular calcification is common in maintenance hemodialysis (HD) patients. Recent studies showed that cartilage oligomeric matrix protein (COMP) could protect blood vessels from calcification, but the role of ADAMTS7 was opposite. We aimed to investigate… read more here.
Keywords: vascular calcification; cartilage oligomeric; calcification; oligomeric matrix ... See more keywords