Injectable freeze‐dried chitosan‐platelet‐rich‐plasma implants improve marrow‐stimulated cartilage repair in a chronic‐defect rabbit model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2814
Abstract: Bone‐marrow stimulation (BMS) improves knee‐joint function but elicits incomplete repair. Liquid chitosan (CS)–glycerol phosphate/blood clots have been shown to improve BMS‐based cartilage repair. Platelet‐rich‐plasma (PRP)—a rich source of growth factors and cytokines—improves recruitment and chondrogenic… read more here.
Keywords: cartilage repair; freeze dried; chronic defect; repair ... See more keywords
Reliability of the MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair techniques—a retrospective observational study
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-021-07688-1
Abstract: To evaluate the reliability of the MOCART 2.0 knee score in the radiological assessment of repair tissue after different cartilage repair procedures. A total of 114 patients (34 females) who underwent cartilage repair of a… read more here.
Keywords: cartilage repair; mocart; reliability; knee score ... See more keywords
Age-dependent differences in response to partial-thickness cartilage defects in a rat model as a measure to evaluate the efficacy of interventions for cartilage repair
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2914-y
Abstract: The objectives of this study are (1) to examine age-dependent longitudinal differences in histological responses after creation of partial-thickness articular cartilage defects (PTCDs) in rats and to use this model (2) to objectively evaluate the… read more here.
Keywords: cartilage repair; week; age dependent; partial thickness ... See more keywords
Cartilage repair using stem cells & biomaterials: advancement from bench to bedside.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05748-1
Abstract: Osteoarthritis (OA) involves gradual destruction of articular cartilagemanifested by pain, stiffness of joints, and impaired movement especially in knees and hips. Non-vascularity of this tissue hinders its self-regenerative capacity and thus, the application of reparative… read more here.
Keywords: repair using; cartilage repair; stem cells; cartilage ... See more keywords
Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices: With cartilage repair products as an example
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.07.031
Abstract: With the interdisciplinary convergence of biology, medicine and materials science, both research and clinical translation of biomaterials are progressing at a rapid pace. However, there is still a huge gap between applied basic research on… read more here.
Keywords: cartilage repair; research; translation; clinical translation ... See more keywords
MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.11.028
Abstract: Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing critical size osteochondral defects in an immunocompetent rat model. Here we investigate the cellular processes modulated by MSC exosomes and the mechanism… read more here.
Keywords: cartilage repair; msc exosomes; proliferation; exosome mediated ... See more keywords
Cell compaction influences the regenerative potential of passaged bovine articular chondrocytes in an ex vivo cartilage defect model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2016.11.002
Abstract: The loss and degradation of articular cartilage tissue matrix play central roles in the process of osteoarthritis (OA). New models for evaluating cartilage repair/regeneration are thus of great value for transferring various culture systems into… read more here.
Keywords: cartilage repair; defect model; cell; cartilage ... See more keywords
Cartilage repair by various concentrations of placenta-derived mesenchymal stem cells and hyaluronic acid hydrogels in a rabbit model
Sign Up to like & getrecommendations! Published in 2017 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.375
Abstract: Background & Aim The placenta-derived mesenchymal stem cells have great interest as a promising cell source for regenerative medicine due to non-invasive collection, readily availability, high expansion capacity, and low immunogenicity. We investigated the feasibility… read more here.
Keywords: cartilage repair; 107 cells; hyaluronic acid; placenta derived ... See more keywords
Novel bioactive glass cross-linked PVA hydrogel with enhanced chondrogenesis properties and application in mice chondrocytes for cartilage repair
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Non-crystalline Solids"
DOI: 10.1016/j.jnoncrysol.2019.119594
Abstract: Abstract The synthetic hydrogel owns huge potential and broad prospects in cartilage tissue engineering due to a series of unique properties, such as bioactivity, the nutrition ions release ability, high mechanical properties and chondrogenesis capacity.… read more here.
Keywords: cartilage repair; bioactive glass; hydrogel; mice chondrocytes ... See more keywords
Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2017.03.005
Abstract: Summary Osteoarthritis is a degenerative disease of joints with destruction of articular cartilage associated with subchondral bone hypertrophy and inflammation. OA is the leading cause of joint pain resulting in significant worsening of the quality-of-life… read more here.
Keywords: cartilage repair; stem cells; cartilage; mesenchymal stem ... See more keywords
Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.182
Abstract: The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone marrow-residing haematopoietic stem cells in that they are… read more here.
Keywords: cartilage repair; stem cells; resident; joint resident ... See more keywords