Accurate Detection of Rare Mutant Alleles by Target Base-Specific Cleavage with the CRISPR/Cas9 System.
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DOI: 10.1021/acssynbio.1c00056
Abstract: The detection of low-frequency somatic mutations enables early diagnosis of disease; however, base-substitution errors that arise during genomic library preparation and high-throughput sequencing can lead to false diagnostic information. To discriminate true genomic alterations from… read more here.
Keywords: mutant alleles; detection; cleavage; base ... See more keywords