Selective loading and processing of prespacers for precise CRISPR adaptation
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DOI: 10.1038/s41586-020-2018-1
Abstract: CRISPR–Cas immunity protects prokaryotes against invading genetic elements 1 . It uses the highly conserved Cas1–Cas2 complex to establish inheritable memory (spacers) 2 – 5 . How Cas1–Cas2 acquires spacers from foreign DNA fragments (prespacers)… read more here.
Keywords: pam sequence; correct orientation; integration; cas1 cas2 ... See more keywords
Unraveling the host-selective toxic interaction of cassiicolin with lipid membranes and its cytotoxicity.
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DOI: 10.1094/phyto-09-21-0397-r
Abstract: Cassiicolin (Cas), a toxin produced by Corynespora cassiicola, is responsible for corynespora leaf fall disease in susceptible rubber trees. Currently, the molecular mechanisms of the cytotoxicity of Cas and its host selectivity have not been… read more here.
Keywords: lipid membranes; cas1 cas2; cytotoxicity; cassiicolin ... See more keywords
Relationship between drug resistance and the clustered, regularly interspaced, short, palindromic repeat-associated protein genes cas1 and cas2 in Shigella from giant panda dung
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DOI: 10.1097/md.0000000000005922
Abstract: Background: To detect drug resistance in Shigella obtained from the dung of the giant panda, explore the factors leading to drug resistance in Shigella, understand the characteristics of clustered, regularly interspaced, short, palindromic repeats (CRISPR),… read more here.
Keywords: drug resistance; cas1 cas2; giant panda; shigella ... See more keywords