Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R
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DOI: 10.1002/advs.202507126
Abstract: The early detection of circulating tumor DNA (ctDNA) at mutant allele frequencies below 0.1% remains a critical challenge, significantly impeding therapeutic decision‐making. To address this limitation, TIDE‐Cas14a—an innovative CRISPR/Cas14a‐based duplex detection system is developed that… read more here.
Keywords: detection; crispr cas14a; cas14a; pik3ca h1047r ... See more keywords