Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01821-4
Abstract: CRISPR‒Cas7-11 is a Type III-E CRISPR-associated nuclease that functions as a potent RNA editing tool. Tetratrico-peptide repeat fused with Cas/HEF1-associated signal transducer (TPR-CHAT) acts as a regulatory protein that interacts with CRISPR RNA (crRNA)-bound Cas7-11… read more here.
Keywords: structural basis; crispr cas7; cas7; tpr chat ... See more keywords
CRISPR RNA binding drives structural ordering that primes Cas7-11 for target cleavage
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf271
Abstract: Abstract Type III-E CRISPR–Cas effectors, referred to as Cas7-11 or giant Repeat-Associated Mysterious Protein, are single proteins that cleave target RNAs (tgRNAs) without nonspecific collateral cleavage, opening new possibilities for RNA editing. Here, biochemical assays… read more here.
Keywords: cas7; crrna; target; crispr rna ... See more keywords