CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.346
Abstract: CRISPR/Cas9 edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC read more here.
Keywords: edited nsg; pdx models; crispr cas9; mice pdx ... See more keywords
Whole-genome sequencing reveals rare off-target mutations in CRISPR/Cas9-edited grapevine
Sign Up to like & getrecommendations! Published in 2021 at "Horticulture Research"
DOI: 10.1038/s41438-021-00549-4
Abstract: The CRISPR (clustered regularly interspaced short palindromic repeats)-associated protein 9 (Cas9) system is a powerful tool for targeted genome editing, with applications that include plant biotechnology and functional genomics research. However, the specificity of Cas9… read more here.
Keywords: crispr cas9; target; edited grapevine; cas9 edited ... See more keywords
CRISPR/Cas9-edited HSPC therapy for hemoglobinopathies
Sign Up to like & getrecommendations! Published in 2019 at "Lab Animal"
DOI: 10.1038/s41684-019-0406-7
Abstract: β-hemoglobinopathies are inherited disorders caused by mutations in the β-globin gene. Sickle cell disease, for example, is the result of deficient hemoglobin (Hb); patients with β-thalassemia produce insufficient amounts of the oxygen-carrying protein. To date,… read more here.
Keywords: hbf; crispr cas9; cas9 edited; gene ... See more keywords
Effect of CRISPR/Cas9-Edited PD-1/PD-L1 on Tumor Immunity and Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.848327
Abstract: Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRISPR/Cas9) gene editing technology implements precise programming of the human genome through RNA guidance. At present, it has been widely used in the construction of animal tumor models,… read more here.
Keywords: crispr cas9; cas9 edited; tumor; effect crispr ... See more keywords