Theophylline-induced synergic activation of guide RNA to control CRISPR/Cas9 function.
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DOI: 10.1039/d1cc01260f
Abstract: Ligand-induced activation of CRISPR/Cas9 function is achieved based on a synergic approach through the integration of the theophylline aptamer into protein-unrecognized regions of guide RNA. This design of allosteric regulation opens a new window towards… read more here.
Keywords: crispr cas9; guide rna; cas9 function;