Active fusions of Cas9 orthologs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.05.306
Abstract: Many recent epigenetic studies utilize the advantages of CRISPR/dCas9 based tools in linking certain epigenetic modification with gene expression regulation. Various multifactorial diseases often contain changed epigenetic signatures at many loci, so tools for simultaneously… read more here.
Keywords: dnmt3a; cas9 orthologs; active fusions; fusions cas9 ... See more keywords
A catalogue of biochemically diverse CRISPR-Cas9 orthologs
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DOI: 10.1038/s41467-020-19344-1
Abstract: Bacterial Cas9 nucleases from type II CRISPR-Cas antiviral defence systems have been repurposed as genome editing tools. Although these proteins are found in many microbes, only a handful of variants are used for these applications.… read more here.
Keywords: crispr; cas9 orthologs; biochemically diverse; diverse crispr ... See more keywords