Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On‐ and Off‐Target Damage
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DOI: 10.1002/bies.202000047
Abstract: Large deletions and genomic re‐arrangements are increasingly recognized as common products of double‐strand break repair at Clustered Regularly Interspaced, Short Palindromic Repeats ‐ CRISPR associated protein 9 (CRISPR/Cas9) on‐target sites. Together with well‐known off‐target editing… read more here.
Keywords: crispr cas9; cas9 target; cas9 editing; target ... See more keywords
Shedding Light on Cas9 Target Search
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DOI: 10.1016/j.bpj.2016.11.427
Abstract: The CRISPR/Cas adaptive immune system provides prokaryotes with a defensive mechanism against invading viruses and plasmids. The invading viral DNA fragments are incorporated into the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) locus in the… read more here.
Keywords: system; crispr; dna; cas9 target ... See more keywords