Long non-coding RNA CASC2 protect ROS-induced Oxidative stress in myocardial infarction by miR-18a/SIRT2.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2252
Abstract: BACKGROUND We aimed to investigate the function and its possible mechanisms of long non-coding RNA (lncRNA) in acute myocardial infarction (AMI) model. METHODS Patients with AMI and normal volunteers were collected from our hospital. Sprague… read more here.
Keywords: induced oxidative; mir 18a; casc2; ros induced ... See more keywords
LncRNA CASC2 inhibited the viability and induced the apoptosis of hepatocellular carcinoma cells through regulating miR‐24‐3p
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26479
Abstract: Cancer susceptibility candidate 2 (CASC2), a recently discovered long non‐coding RNA (lncRNA), was confirmed to play numerous roles in several human cancers. However, the involvement and concrete mechanism of CASC2 in hepatocellular carcinoma (HCC) still… read more here.
Keywords: hepatocellular carcinoma; hcc; viability; mir ... See more keywords
Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi‐organ dysfunction, disease severity, and mortality in sepsis patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24569
Abstract: Long noncoding RNA (lncRNA) cancer susceptibility candidate gene 2 (CASC2) inhibits inflammation and multi‐organ dysfunction in various ways. The present study was intended to explore the potency of blood lncRNA CASC2 as a biomarker for… read more here.
Keywords: casc2 biomarker; casc2; organ dysfunction; multi organ ... See more keywords
Long non-coding RNA CASC2 targeting miR-18a suppresses glioblastoma cell growth, metastasis and EMT in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00077-8
Abstract: Long non-coding RNAs (lncRNAs) cancer susceptibility candidate 2 (CASC2) has been characterized as a tumor suppressor in glioma. Although CASC2 may predict the prognosis of glioma patients, the role and mechanism of CASC2 in human… read more here.
Keywords: cell growth; mir 18a; casc2; metastasis ... See more keywords
LncRNA CASC2 inhibits autophagy and promotes apoptosis in non-small cell lung cancer cells via regulating the miR-214/TRIM16 axis
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra09573f
Abstract: Background: Dysregulated long noncoding RNAs (lncRNAs) have been frequently observed in various cancers including non-small cell lung cancer (NSCLC) and are closely associated with cancer progression. Previous studies also found that low expression of lncRNA… read more here.
Keywords: non small; apoptosis; casc2; mir 214 ... See more keywords
Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2021.1995130
Abstract: ABSTRACT Nuclear factor I (NFI) family is emerging found playing oncogenic or tumor-suppressive potential in cancers. However, the function and underlying mechanisms of NFIC, in the progression of Lung Squamous Cell Carcinoma (LUSC) remain unclear.… read more here.
Keywords: cell; squamous cell; casc2; lusc ... See more keywords
Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2022075
Abstract: ABSTRACT Rheumatoid arthritis (RA) is a perennial inflammatory condition. Preliminary research indicated that long non-coding (lnc)RNA cancer susceptibility candidate 2 (CASC2) was downregulated in the serum of RA patients. Our study was designed to reveal… read more here.
Keywords: mir 18a; non coding; casc2; rheumatoid arthritis ... See more keywords
Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1018-x
Abstract: BackgroundIn this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.MethodsThe expression of lncRNAs or mRNAs was detected by qRT-PCR, and western blot analysis or… read more here.
Keywords: cell proliferation; casc2; pulmonary artery; cell ... See more keywords
Long non-coding RNA CASC2 serves as a ceRNA of microRNA-21 to promote PDCD4 expression in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s198970
Abstract: Background: Oral squamous cell carcinoma (OSCC) is a common oral disease with high morbidity and mortality. Recently, long non-coding RNAs (lncRNAs) were identified as critical regulators in OSCC tumorigenesis. The present study aimed to work… read more here.
Keywords: expression; pdcd4; oral squamous; cell ... See more keywords
The lncRNA CASC2 Modulates Hepatocellular Carcinoma Cell Sensitivity and Resistance to TRAIL Through Apoptotic and Non-Apoptotic Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.726622
Abstract: The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been widely concerned as a tumor therapy because of its ability of selective triggering cancer cell apoptosis; nevertheless, hepatocellular carcinoma (HCC) exhibits acquired resistance to… read more here.
Keywords: trail; cell; apoptosis; hcc ... See more keywords
Long non-coding RNA CASC2 enhances berberine-induced cytotoxicity in colorectal cancer cells by silencing BCL2
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10326
Abstract: Berberine, a natural isoquinoline alkaloid derived from Berberis species, has been reported to have anticancer effects. However, the mechanisms of action in human colorectal cancer (CRC) are not well established to date. In the present… read more here.
Keywords: berberine induced; bcl2; casc2; cell ... See more keywords