MOF‐Immobilized Two‐in‐One Engineered Enzymes Enhancing Activity of Biocatalytic Cascade for Tumor Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203035
Abstract: Biocatalytic systems based on enzyme cascade reactions have attracted growing interest in the field of biocatalytic medicine. However, it is a major challenge to reasonably construct enzyme cascade reactions with high stability, selectivity, and catalytic… read more here.
Keywords: enzyme cascade; gox fe0; two one; cascade ... See more keywords
Constructing Spatiotemporally Controllable Biocatalytic Cascade in RBC Nanovesicles for Precise Tumor Therapy Based on Reversibly Induced Glucose Oxidase-Magnetoferritin Dimers.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300205
Abstract: Chemodynamic therapy is a promising tumor treatment strategy. However, it remains a great challenge to overcome the unavoidable off-target damage towards normal tissues. In our work we discover that magnetoferritin (M-HFn, biomimic peroxidase) can form… read more here.
Keywords: controllable biocatalytic; cascade; spatiotemporally controllable; therapy ... See more keywords
Metal‐Free [2 + 3] Dipolar Cycloaddition/Denitration Cascade between Nitroalkenes and α‐Diazoesters: Regioselective Access to Functionalized NH‐Pyrazoles
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400077
Abstract: An efficient one‐pot synthesis of 1H‐pyrazoles has been realized via cascade cyclocondensation of β‐nitroalkenes as C2 synthon with α‐diazoesters as C1N2 unit. The reaction proceeds via concomitant formation of two new (C‐N & C‐C) bonds… read more here.
Keywords: dipolar cycloaddition; cascade; denitration; metal free ... See more keywords
Engineering of an H2O2 auto‐scavenging in vivo cascade for pinoresinol production
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26319
Abstract: Pinoresinol is a natural lignan with a high market value that has potential pharmacological and food supplement applications. Pinoresinol is currently isolated from plants, which suffers from low efficiency and yield. To produce pinoresinol from… read more here.
Keywords: pinoresinol production; vivo; cascade; engineering h2o2 ... See more keywords
Development of an aminotransferase-driven biocatalytic cascade for deracemization of d,l-phosphinothricin.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28432
Abstract: 2-oxo-4-[(hydroxy)(methyl)phosphinoyl]butyric acid (PPO) is the essential precursor keto acid for the asymmetric biosynthesis of herbicide l-phosphinothricin (l-PPT). Developing a biocatalytic cascade for PPO production with high efficiency and low cost is highly desired. Herein, a… read more here.
Keywords: ppo; cascade; biocatalytic cascade; aminotransferase driven ... See more keywords
Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000309
Abstract: The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450‐mediated cyclisation cascade that crosslinks aromatic side chains within this… read more here.
Keywords: crosslinking cascade; biosynthesis; antibiotic crosslinking; cascade ... See more keywords
Polyelectrolytes Tailored Enzyme Cascades with Enhanced Stability and Activity for One‐pot Synthesis
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201801532
Abstract: Cascade enzymes from the same origin or different resources often differ in their pH windows of stability and activity, thus impeding one‐pot enzyme cascade reactions. Here we present a method to assemble enzyme cascades using… read more here.
Keywords: stability activity; activity; one pot; cascade ... See more keywords
One Pot Asymmetric Synthesis of (R)‐Phenylglycinol from Racemic Styrene Oxide via Cascade Biocatalysis
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900492
Abstract: (R)‐Phenylglycinol is an important chiral building block for pharmaceutical and fine chemical industry, and its efficient synthesis from cheap and commercially available starting materials is challenging and highly desirable. Herein, a new three‐step one‐pot cascade… read more here.
Keywords: styrene oxide; racemic styrene; cascade; phenylglycinol ... See more keywords
Landscape patterns in top-down control of decomposition: omnivory disrupts a tropical detrital-based trophic cascade.
Sign Up to like & getrecommendations! Published in 2019 at "Ecology"
DOI: 10.1002/ecy.2723
Abstract: Detrital-based trophic cascades are often considered weak or absent in tropical stream ecosystems because of the prevalence of omnivorous macroconsumers and the dearth of leaf-shredding insects. In this study, we isolate top-down effects of three… read more here.
Keywords: control; cascade; decomposition rates; detrital based ... See more keywords
Synthesis of (E)‐Enaminoesters by a 1,6‐Addition/Fragmentation Cascade Involving Coumalic Acid Esters and Secondary Amines
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400435
Abstract: Coumalic acid methyl ester (methyl coumalate), a biomass‐derived building block, was converted into (E)‐enaminoesters by an original uncatalyzed stereoselective 1,6‐addition/fragmentation cascade involving secondary amines. The transformation occurred under useful experimental conditions as a simple heating… read more here.
Keywords: cascade; coumalic acid; fragmentation; addition ... See more keywords
Chiral Thiourea Catalyzed Enantioselective Cascade Synthesis of 2,3‐Dihydrobenzofurans
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202401391
Abstract: We established an efficient asymmetric cascade pathway for the construction of trans‐2,3‐dihydrobenzofurans. This reaction proceeds via a Michael addition followed by an oxa‐substitution, employing in‐situ generated pyridinium ylide and ortho‐hydroxy chalcone derivatives in the presence… read more here.
Keywords: catalyzed enantioselective; cascade; enantioselective cascade; chiral thiourea ... See more keywords