Ultrasound-Triggered Cascade Amplification of Nanotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303158
Abstract: Ultrasound (US)-triggered cascade amplification of nanotherapies has attracted considerable attention as an effective strategy for cancer treatment. With the remarkable advances in materials chemistry and nanotechnology, a large number of well-designed nanosystems have emerged that… read more here.
Keywords: amplification nanotherapy; triggered cascade; amplification; ultrasound triggered ... See more keywords
Electrochemiluminescence Cascade Amplification Platform for Detection of Dual-microRNA and Operation of Concatenated Logic Circuit.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04242
Abstract: The detection of multiple biomarkers is of great significance to the accurate diagnosis of diseases. Herein, in this work, we constructed an electrochemiluminescence (ECL) cascade amplification platform for dual acute myocardial infarction (AMI)-related microRNA detection.… read more here.
Keywords: amplification; cascade amplification; detection; logic circuit ... See more keywords
Magnetic DNA Nanomachine for On-Particle Cascade Amplification-Based Ferromagnetic Resonance Detection of Plant MicroRNA.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00065
Abstract: Plant microRNAs play critical roles in post-transcriptional gene regulation of many processes, thus motivating the development of accurate and user-friendly microRNA detection methods for better understanding of, e.g., plant growth, development, and abiotic/biotic stress responses.… read more here.
Keywords: magnetic dna; amplification; plant; cascade amplification ... See more keywords
Photoelectrochemical Biosensor Based on TiO2/P5FIn with a Cascade Amplification Strategy for Simultaneous Detection of GSH and E2 Analytes of Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c06302
Abstract: In this work, a photoelectrochemical (PEC) sensor for ovarian cancer detection was constructed based on TiO2/poly(5-formylindole) (P5FIn)heterojunction using cascade amplification. The combined detection of multiple markers instead of a single detection mode can improve diagnostic… read more here.
Keywords: detection; cascade amplification; based tio2; ovarian cancer ... See more keywords
Engineering of ATP-Powered Photosensitizer for Targeted Recycling Activatable Imaging of MicroRNA and Controllable Cascade Amplification Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b01692
Abstract: Owing to the low abundance of microRNAs (miRNAs) in living tumor cells, the development of intracellular cancer-relevant miRNA stimuli-activatable photosensitizers (PSs) for accurate imaging and efficient photodynamic therapy (PDT) of tumors in vivo is extremely… read more here.
Keywords: cascade amplification; atp powered; photodynamic therapy; cascade ... See more keywords
Target-Induced Cascade Amplification for Homogeneous Virus Detection.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b03805
Abstract: Detection of virus with high sensitivity is critical for the prevention and treatment of the related disease. Two homogeneous target-induced cascade amplification methods were proposed for the detection of enterovirus 71 and coxsackievirus B3. These… read more here.
Keywords: cascade amplification; detection; induced cascade; target induced ... See more keywords
Cascade amplification of therapeutic payloads for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08735-z
Abstract: Achieving sufficient therapeutic payload delivery remains a significant challenge in gene therapy, particularly for cancer immunotherapy, where payload thresholds are critical for efficacy. To address this, we developed a Cascade Amplification of Therapeutic Payloads (CATP)… read more here.
Keywords: therapeutic payloads; cascade amplification; cancer immunotherapy; amplification ... See more keywords
Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00647b
Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we… read more here.
Keywords: drug activation; cascade amplification; polyprodrug; activation ... See more keywords