Visible Light‐Induced the Radical Cascade Cyclization of 2‐Isocyanobiaryls via 1,2‐Hydrogen Atom Transfer
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DOI: 10.1002/ejoc.202500735
Abstract: Phenanthridines, as important structural moieties of many naturally occurring products, pharmaceuticals, and functionalized polycyclic heteroarenes, have attracted considerable attention among chemists due to their significant potential in pharmaceutical and material chemistry. The hydrogen atom transfer… read more here.
Keywords: chemistry; isocyanobiaryls via; radical cascade; cyclization isocyanobiaryls ... See more keywords
Gold-Catalyzed Oxidative Cascade Cyclization of 1,3-Diynamides: Polycyclic N-Heterocycle Synthesis via Construction of a Furopyridinyl Core.
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DOI: 10.1021/acs.orglett.0c01086
Abstract: A facile and practical approach to construct a furopyridinyl motif through a gold-catalyzed cascade cyclization of easily accessible diynamides is described. This strategy offers a straightforward approach to furo[2,3-c]isoquinoline and 6H-furo[3',2':5,6]pyrido[3,4-b]indole derivatives. The reaction could… read more here.
Keywords: furopyridinyl; cascade cyclization; gold catalyzed; catalyzed oxidative ... See more keywords
Silver-Catalyzed Cascade Cyclization Reaction of Isocyanides with Sulfoxonium Ylides: Synthesis of 3-Aminofurans and 4-Aminoquinolines.
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DOI: 10.1021/acs.orglett.0c02835
Abstract: A silver-catalyzed cascade cyclization reaction of isocyanides with sulfoxonium ylides has been developed for the first time. This reaction provides a new and efficient method for the construction of highly functionalized 3-aminofurans and 4-aminoquinolines from… read more here.
Keywords: silver catalyzed; reaction isocyanides; cascade cyclization; cyclization reaction ... See more keywords
Synthesis of Noraugustamine and Development of an Oxidative Heck/Aza-Wacker Cascade Cyclization.
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DOI: 10.1021/acs.orglett.2c00948
Abstract: Radical and transition metal-catalyzed cascade cyclization strategies were investigated with respect to the synthesis of the tetracyclic core of the augustamine-type Amaryllidaceae alkaloids. These studies resulted in the synthesis of noraugustamine and the development of… read more here.
Keywords: development oxidative; cascade cyclization; oxidative heck; noraugustamine development ... See more keywords
Iodine-Mediated Multicomponent Cascade Cyclization and Sulfenylation/Selenation: Synthesis of Imidazo[2,1-a]isoquinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01681
Abstract: A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl methyl ketones, isoquinolin-1-amine, and sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds and one C-S/C-Se bond has been reported.… read more here.
Keywords: sulfenylation; cyclization sulfenylation; cascade cyclization; multicomponent cascade ... See more keywords
Copper-Catalyzed Decarboxylative Cascade Cyclization of Propargylic Cyclic Carbonates/Carbamates with Pyridinium 1,4-Zwitterionic Thiolates to Fused Polyheterocyclic Structures.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01959
Abstract: A copper-catalyzed decarboxylative cascade cyclization of propargylic cyclic carbonates/carbamates with pyridinium 1,4-zwitterionic thiolates is developed. A range of fused polyheterocyclic compounds are obtained in moderate to good yields with excellent diastereoselectivities. Of particular note is… read more here.
Keywords: cascade cyclization; decarboxylative cascade; catalyzed decarboxylative; copper catalyzed ... See more keywords
B2pin2-Mediated Cascade Cyclization/Aromatization Reaction: Facial Access to Functionalized Indolizines.
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DOI: 10.1021/acs.orglett.2c02905
Abstract: Herein, a B2pin2-mediated radical cascade cyclization/aromatization reaction of enaminone with pyridine is described. This strategy provides a practical way for the construction of valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions, which could… read more here.
Keywords: aromatization reaction; cascade cyclization; reaction; functionalized indolizines ... See more keywords
Cp*Co(III)-Catalyzed C(8)-Nucleophilic Cascade Cyclization of Quinoline N-Oxide with 1,6-Enyne.
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DOI: 10.1021/acs.orglett.3c00305
Abstract: The C(8)-selective nucleophilic cascade cyclization of quinoline N-oxide with easily derived 1,6-enyne from phenol derivatives is demonstrated. A variety of quinoline N-oxide and alkynes are discovered to be suitable for producing a library of quinoline… read more here.
Keywords: quinoline oxide; cascade cyclization; cyclization quinoline; nucleophilic cascade ... See more keywords
EDA Complex-Promoted Cascade Cyclization of Alkynes Enabling the Rapid Assembly of 3-Sulfonylindoles and Vinyl Sulfone Oxindoles.
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DOI: 10.1021/acs.orglett.4c01977
Abstract: Herein, we disclose a photoinduced radical cascade cyclization of alkynes with sulfinates via a novel EDA complex for the synthesis of various 3-sulfonylindoles and vinyl sulfone oxindoles, which are crucial motifs in medicinal and biological… read more here.
Keywords: cyclization alkynes; sulfonylindoles vinyl; vinyl sulfone; cyclization ... See more keywords
Visible-Light-Induced Cascade Cyclization of 1-(2-(Arylethynyl)benzoyl)indoles into Sulfonated Benazepino[1,2-a]indolones.
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DOI: 10.1021/acs.orglett.4c04145
Abstract: 1-(2-(Arylethynyl)benzoyl)indoles were developed as an innovative scaffold for radical cascade cyclization under visible-light and mild conditions, enabling efficient synthesis of sulfonated benazepino[1,2-a]indolones. This method operates at room temperature and demonstrates broad substrate compatibility and scalability,… read more here.
Keywords: benazepino indolones; sulfonated benazepino; visible light; arylethynyl benzoyl ... See more keywords
Iron(III)-Mediated Nucleophilic Cascade Cyclization of Tertiary Enamides with Diselenides for the Construction of 3-Seleno-2-pyridones.
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DOI: 10.1021/acs.orglett.4c04446
Abstract: An iron(III)-mediated nucleophilic cascade cyclization of N-propiolyl enamides with various diselenides was developed, which provides an efficient way to construct seleno-heterocycles. A mechanism study shows that the cascade process involves the selective addition of diselenides… read more here.
Keywords: seleno; iron iii; iii mediated; mediated nucleophilic ... See more keywords