Gold-Catalyzed Oxidative Cascade Cyclization of 1,3-Diynamides: Polycyclic N-Heterocycle Synthesis via Construction of a Furopyridinyl Core.
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DOI: 10.1021/acs.orglett.0c01086
Abstract: A facile and practical approach to construct a furopyridinyl motif through a gold-catalyzed cascade cyclization of easily accessible diynamides is described. This strategy offers a straightforward approach to furo[2,3-c]isoquinoline and 6H-furo[3',2':5,6]pyrido[3,4-b]indole derivatives. The reaction could… read more here.
Keywords: furopyridinyl; cascade cyclization; gold catalyzed; catalyzed oxidative ... See more keywords
Silver-Catalyzed Cascade Cyclization Reaction of Isocyanides with Sulfoxonium Ylides: Synthesis of 3-Aminofurans and 4-Aminoquinolines.
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DOI: 10.1021/acs.orglett.0c02835
Abstract: A silver-catalyzed cascade cyclization reaction of isocyanides with sulfoxonium ylides has been developed for the first time. This reaction provides a new and efficient method for the construction of highly functionalized 3-aminofurans and 4-aminoquinolines from… read more here.
Keywords: silver catalyzed; reaction isocyanides; cascade cyclization; cyclization reaction ... See more keywords
Synthesis of Noraugustamine and Development of an Oxidative Heck/Aza-Wacker Cascade Cyclization.
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DOI: 10.1021/acs.orglett.2c00948
Abstract: Radical and transition metal-catalyzed cascade cyclization strategies were investigated with respect to the synthesis of the tetracyclic core of the augustamine-type Amaryllidaceae alkaloids. These studies resulted in the synthesis of noraugustamine and the development of… read more here.
Keywords: development oxidative; cascade cyclization; oxidative heck; noraugustamine development ... See more keywords
Iodine-Mediated Multicomponent Cascade Cyclization and Sulfenylation/Selenation: Synthesis of Imidazo[2,1-a]isoquinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01681
Abstract: A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl methyl ketones, isoquinolin-1-amine, and sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds and one C-S/C-Se bond has been reported.… read more here.
Keywords: sulfenylation; cyclization sulfenylation; cascade cyclization; multicomponent cascade ... See more keywords
Copper-Catalyzed Decarboxylative Cascade Cyclization of Propargylic Cyclic Carbonates/Carbamates with Pyridinium 1,4-Zwitterionic Thiolates to Fused Polyheterocyclic Structures.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01959
Abstract: A copper-catalyzed decarboxylative cascade cyclization of propargylic cyclic carbonates/carbamates with pyridinium 1,4-zwitterionic thiolates is developed. A range of fused polyheterocyclic compounds are obtained in moderate to good yields with excellent diastereoselectivities. Of particular note is… read more here.
Keywords: cascade cyclization; decarboxylative cascade; catalyzed decarboxylative; copper catalyzed ... See more keywords
B2pin2-Mediated Cascade Cyclization/Aromatization Reaction: Facial Access to Functionalized Indolizines.
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DOI: 10.1021/acs.orglett.2c02905
Abstract: Herein, a B2pin2-mediated radical cascade cyclization/aromatization reaction of enaminone with pyridine is described. This strategy provides a practical way for the construction of valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions, which could… read more here.
Keywords: aromatization reaction; cascade cyclization; reaction; functionalized indolizines ... See more keywords
Cp*Co(III)-Catalyzed C(8)-Nucleophilic Cascade Cyclization of Quinoline N-Oxide with 1,6-Enyne.
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DOI: 10.1021/acs.orglett.3c00305
Abstract: The C(8)-selective nucleophilic cascade cyclization of quinoline N-oxide with easily derived 1,6-enyne from phenol derivatives is demonstrated. A variety of quinoline N-oxide and alkynes are discovered to be suitable for producing a library of quinoline… read more here.
Keywords: quinoline oxide; cascade cyclization; cyclization quinoline; nucleophilic cascade ... See more keywords
Copper-Mediated Nucleophilic Addition/Cascade Cyclization of Aryl Diynes.
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DOI: 10.1021/acs.orglett.6b03787
Abstract: Treatment of diyne substrates with sulfinate salts under the action of copper(II) triflate results in a cascade cyclization reaction. The reaction involves nucleophilic addition of the sulfinate and formation of two new C-C bonds with… read more here.
Keywords: copper mediated; mediated nucleophilic; nucleophilic addition; cascade cyclization ... See more keywords
Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji–Trost Cascade Cyclization
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DOI: 10.1021/acs.orglett.8b02232
Abstract: A stereoselective intramolecular Tsuji–Trost cascade cyclization of (homo)allylic vicinal diacetates with a pendant β-ketoamide or related carbon nucleophile to give γ-lactam-fused vinylcyclopropanes is reported. In addition to two new rings, the products contain three new… read more here.
Keywords: cascade cyclization; fused vinylcyclopropanes; tsuji trost; trost cascade ... See more keywords
In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds.
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DOI: 10.1021/acs.orglett.8b03461
Abstract: A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in… read more here.
Keywords: otf catalyzed; cascade cyclization; construction; oxatricyclic compounds ... See more keywords
Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2,1-a]isoquinolin-6(5H)-ones.
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DOI: 10.1039/c8cc10243k
Abstract: A simple and efficient decarboxylative radical addition/cyclization strategy was developed, by which a wide range of benzimidazo[2,1-a]isoquinoline-6(5H)-ones were prepared in one-pot via reaction of functionalized 2-arylbenzoimidazoles and carboxylic acids in the presence of K2S2O8/AgNO3 under… read more here.
Keywords: silver catalyzed; radical cascade; cascade cyclization; catalyzed decarboxylative ... See more keywords