A Four-Component Cascade C-H Functionalization/Cyclization/Nucleophilic Substitution Reaction To Construct α-Functionalized Tetrahydroquinolines by the Strategy of in Situ Directing Group Formation.
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DOI: 10.1021/acs.orglett.7b00226
Abstract: A four-component cascade C-H functionalization/cyclization/nucleophilic substitution reactions of anilines, carboxylic anhydrides, propenol, and alkohols have been developed by a strategy of in situ directing group formation, affording an efficient and convenient synthesis of α-alkoxyl tetrahydroquinolines… read more here.
Keywords: functionalization cyclization; four component; component cascade; cyclization nucleophilic ... See more keywords
Organocatalytic Cascade β-Functionalization/Aromatization of Pyrrolidines via Double Hydride Transfer.
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DOI: 10.1021/acs.orglett.9b03918
Abstract: An unprecedented cascade β-functionalization/aromatization reaction of N-arylpyrrolidines was established. A series of β-substituted arylpyrroles embedded with trifluoromethyl groups are provided directly from N-arylpyrrolidines. The deuterium-labeling experiments indicate that sequential double hydride transfer processes serve as… read more here.
Keywords: double hydride; hydride transfer; functionalization aromatization; cascade functionalization ... See more keywords