Formal Synthesis of Ecteinascidin 743 via an Intramolecular Cascade Heck Reaction to Construct the Diazabicyclo[3.3.1]nonane Framework.
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DOI: 10.1021/acs.orglett.2c03357
Abstract: A synthetic route to ecteinascidin 743 has been established via an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane skeleton while controlling the two contiguous stereogenic centers. The strategically formed five-membered ring was oxidatively cleaved… read more here.
Keywords: cascade heck; heck reaction; via intramolecular; reaction construct ... See more keywords