A Guanosine‐Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment—A Study in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103485
Abstract: Diabetic foot ulcers infected with antibiotic‐resistant bacteria form a severe complication of diabetes. Antimicrobial‐loaded hydrogels are used as a dressing for infected wounds, but the ongoing rise in the number of antimicrobial‐resistant infections necessitates new,… read more here.
Keywords: reaction; cascade reaction; quadruplex hydrogel; guanosine quadruplex ... See more keywords
A Biocatalytic Cascade Reaction to Access a Valuable Long‐Chain ω‐Hydroxy Fatty Acid
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DOI: 10.1002/cctc.202000745
Abstract: Environmentally‐friendly processes for the manufacturing of valuable industrial compounds like ω‐hydroxy fatty acids (ω‐OHFAs) are highly desirable. Herein, we present such an approach by establishing a two‐step enzymatic cascade reaction for the production of 2,15,16‐trihydroxy… read more here.
Keywords: biocatalytic cascade; acid; hydroxy fatty; cascade reaction ... See more keywords
Synthesis of Phenanthridines through Palladium‐Catalyzed Cascade Reaction of 2‐Halo‐N‐Ms‐arylamines with Benzyl Halides/Sulfonates
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601608
Abstract: An efficient palladium-catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2-halo-N-Ms-arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one-pot fashion in moderate to… read more here.
Keywords: halo arylamines; cascade reaction; halides sulfonates; palladium catalyzed ... See more keywords
Injectable Hydrogel Based on Defect-Rich Multi-Nanozymes for Diabetic Wound Healing via an Oxygen Self-Supplying Cascade Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200165
Abstract: Diabetic wound healing remains challenging owing to the risk for bacterial infection, hypoxia, excessive glucose levels, and oxidative stress. Glucose-activated cascade reactions can consume glucose and eradicate bacteria, avoiding the direct use of hydrogen peroxide… read more here.
Keywords: cascade reaction; wound healing; bsa; diabetic wound ... See more keywords
Palladium-catalyzed regioselective cascade reaction of carbon dioxide, amines and allenes for the synthesis of functionalized carbamates
Sign Up to like & getrecommendations! Published in 2020 at "Science China Chemistry"
DOI: 10.1007/s11426-019-9679-6
Abstract: A palladium-catalyzed regioselective three-component cascade reaction of carbon dioxide, amines and allenes has been developed, providing an expedient and practical method for the construction of a range of functionalized carbamates containing dihydrobenzofuran or indole moiety… read more here.
Keywords: dioxide amines; reaction carbon; cascade reaction; carbon dioxide ... See more keywords
Screening of perhydrolases to optimize glucose oxidase-perhydrolase-in situ chemical oxidation cascade reaction system and its application in melanin decolorization.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2021.01.013
Abstract: A novel glucose oxidase (GOD)-perhydrolase-in situ chemical oxidation (ISCO) cascade reaction system was designed, optimized, and verified the operation feasibility in this research. Among the determined four perhydrolases, acyltransferase from Mycobacterium smegmatis (MsAcT) displayed the… read more here.
Keywords: cascade reaction; reaction system; reaction; god msact ... See more keywords
Boosted activity by engineering the enzyme microenvironment in cascade reaction: A molecular understanding
Sign Up to like & getrecommendations! Published in 2021 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2021.06.004
Abstract: Engineering of enzyme microenvironment can surprisingly boost the apparent activity. However, the underlying regulation mechanism is not well-studied at a molecular level so far. Here, we present a modulation of two model enzymes of cytochrome… read more here.
Keywords: engineering enzyme; enzyme microenvironment; activity; cascade reaction ... See more keywords
Novel cascade reaction-based fluorescent cyanine chemosensor for cysteine detection and bioimaging in living system.
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DOI: 10.1016/j.talanta.2020.121291
Abstract: Precise detection of intracellular Cys will be helpful to accurately assess the physiological functions in the physiological and pathological processes. Herein, a new probe Meoeth-Cy-OBz-oCl capable of Cys sensing with high selectivity over other mercaptoamino-acid… read more here.
Keywords: detection; cascade reaction; cys; meoeth obz ... See more keywords
Lewis acid-promoted cascade reaction for the synthesis of Michael acceptors and its application in a dimerization reaction
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DOI: 10.1016/j.tet.2017.05.017
Abstract: Abstract An efficient Lewis acid-promoted cascade reaction with dimethyl sulfoxide as a methylene source for the synthesis of Michael acceptors is reported. The key to developing this procedure is the selection of a mild base… read more here.
Keywords: michael; lewis acid; cascade reaction; promoted cascade ... See more keywords
B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.060
Abstract: Abstract The B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the construction of 2,4,6-triarylpyridines under metal-/solvent-free conditions has been successfully achieved. The advantages of this strategy include good functional group tolerance, low catalyst… read more here.
Keywords: deamination cyclization; cascade reaction; cyclization cascade; c6f5 catalyzed ... See more keywords
Gold catalyzed cascade reaction of 2-Alkynyl arylazides with 1,2,3-Triazoles to provide N- and N-Indol-3-yl 1,2,3-Triazole derivatives
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DOI: 10.1016/j.tetlet.2020.151851
Abstract: Abstract A new method was developed to prepare N1 and N2-indol-3-yl 1,2,3-trizole products through gold catalyzed cascade reaction of o-alkynyl arylazides with 1,2,3-triazoles, in which, the in-situ generated α-imino gold carbene intermediate was intercepted by… read more here.
Keywords: cascade reaction; arylazides triazoles; reaction alkynyl; catalyzed cascade ... See more keywords