Creating Oxidase–Peroxidase Fusion Enzymes as a Toolbox for Cascade Reactions
Sign Up to like & getrecommendations! Published in 2017 at "Chembiochem"
DOI: 10.1002/cbic.201700478
Abstract: A set of bifunctional oxidase–peroxidases has been prepared by fusing four distinct oxidases to a peroxidase. Although such fusion enzymes have not been observed in nature, they could be expressed and purified in good yields.… read more here.
Keywords: oxidase peroxidase; cascade reactions; peroxidase; fusion enzymes ... See more keywords
Enzymatic Generation of Double‐Modified AdoMet Analogues and Their Application in Cascade Reactions with Different Methyltransferases
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200511
Abstract: Methyltransferases (MTases) have become an important tool for site‐specific alkylation and biomolecular labelling. In biocatalytic cascades with methionine adenosyltransferases (MATs), transfer of functional moieties has been realized starting from methionine analogues and ATP. However, the… read more here.
Keywords: generation double; adomet analogues; cascade reactions; double modified ... See more keywords
Cascade Reactions Catalyzed by Planar Metal-Organic Framework Hybrid Architecture for Combined Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202004016
Abstract: Chemical transformation in cellular environment is critical for regulating biological processes and metabolic pathways. Harnessing biocatalytic cascades to produce chemicals of interest has become a research focus to benefit industrial and pharmaceutic areas. Nanoreactors, which… read more here.
Keywords: therapy; hybrid architecture; metal organic; cascade reactions ... See more keywords
Organocatalytic Asymmetric Cascade Reactions Based on Gamma-Nitro Carbonyl Compound.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical record"
DOI: 10.1002/tcr.201800047
Abstract: The significant advancements in asymmetric organocascade reactions have been accomplished during the past decades, paving the way to the efficient and stereoselective construction of structurally complex scaffolds from simple and readily available starting materials. Nitro-containing… read more here.
Keywords: organocatalytic asymmetric; cascade reactions; nitro containing; reactions based ... See more keywords
Synthesis of original polycycles containing five-, six- and seven-membered rings through cyclocarbopalladations/C–H activation cascade reactions
Sign Up to like & getrecommendations! Published in 2017 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2017.01.005
Abstract: Abstract Different types of starting materials have been designed and their ability to undergo cascade reactions has been investigated. New polycycles containing five-, six-, and seven-membered rings are described via original cascade reactions. The process… read more here.
Keywords: cascade reactions; polycycles containing; containing five; seven membered ... See more keywords
Cascade reactions leading to the mechanism of action of vinaxanthone and xanthofulvin, natural products that drive nerve repair
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.02.068
Abstract: Abstract The natural products vinaxanthone and xanthofulvin promote regeneration in animal models of spinal cord injury and corneal transplant. However, inhibition of the initially described biological target of these compounds, semaphorin 3A, does not fully… read more here.
Keywords: cascade reactions; natural products; vinaxanthone xanthofulvin; leading mechanism ... See more keywords
Cascade reactions for constructing heterocycles containing a pyrimidino-pyrazino-pyrimidine core using 1,2,4-triazole scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151089
Abstract: Abstract The regioselective cyclocondensation of aminoethyl-1,2,4-triazoles and glyoxal provides pentacyclic heterocycles in which two 7,8-dihydro-5H-6λ2-[1,2,4]triazolo[1,5-c]pyrimidine systems are connected through CH(OH) bridges generating a central piperazine-2,5-diol ring. The structure of the new compounds was elucidated based… read more here.
Keywords: containing pyrimidino; cascade reactions; reactions constructing; pyrimidine ... See more keywords
Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00324
Abstract: Inspired by the structure of eukaryotic cells, multicompartmental microcapsules have gained increasing attention. However, challenges remain in the fabrication of "all-aqueous" (i.e., oil-free) microcapsules composed of accurately adjustable hierarchical compartments. This study reports on multicompartmental… read more here.
Keywords: enzymatic cascade; gas shearing; multicompartmental microcapsules; cascade reactions ... See more keywords
Direct Synthesis of Propen-2-yl Sulfones through Cascade Reactions Using Calcium Carbide as an Alkyne Source.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01915
Abstract: A simple method for the construction of propen-2-yl sulfones through cascade reactions of calcium carbide with arylsulfonylhydrazones using copper as a mediator is described. The salient features of this protocol are the use of readily… read more here.
Keywords: sulfones cascade; cascade reactions; calcium carbide; propen sulfones ... See more keywords
Synthesis of Bridged Oxabicycles via Cascade Reactions involving O-Acyloxocarbenium Ion Intermediates.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03061
Abstract: Compared to related electrophilic species, O-acyloxocarbenium ions (AOIs) have been much less utilized in organic synthesis due to the lack of an efficient formation method. Here, we present a facile and simple approach for the… read more here.
Keywords: synthesis bridged; reactions involving; via cascade; cascade reactions ... See more keywords
1,2-Diamines as the Amine Sources in Amidation and Rhodium-Catalyzed Asymmetric Reductive Amination Cascade Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01728
Abstract: The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and asymmetric reductive amination (ARA) cascade reactions of diamines and ketoesters, we deployed sets of additives… read more here.
Keywords: asymmetric reductive; reductive amination; amidation; cascade reactions ... See more keywords