Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202418229
Abstract: Hydrogen selenide (H2Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such as high‐dose toxicity and short half‐life. Herein, a polymeric H2Se delivery nanogel (H2Se‐NG) incorporated with aldehyde‐modified selenobenzamide… read more here.
Keywords: h2se delivery; dual cascade; multidrug resistant; cascade responsive ... See more keywords
Inorganic and Metal-Organic Nanocomposites for Cascade-Responsive Imaging and Photochemical Synergistic Effects.
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b03719
Abstract: Porphyrins coordinated with platinum(II) chemotherapeutic drugs are attractive for the development of photosensitizers for photodynamic therapy (PDT) of cancer. In this paper, inorganic and metal-organic nanocomposites were synthesized with cascade-responsive imaging and photochemical synergistic effects.… read more here.
Keywords: cascade responsive; metal organic; organic nanocomposites; metal ... See more keywords
Cascade Responsive Photosensitizer for Precise Delivery and Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00316
Abstract: We report a tumor microenvironment-responsive photosensitizer (1) as a molecular chameleon with cascade transformation capabilities for precision-controlled photosensitizer delivery. 1 is encapsulated in a pH-responsive surfactant to form 1a with a PEGylated surface that does… read more here.
Keywords: photosensitizer; delivery; responsive photosensitizer; cascade responsive ... See more keywords
Cascade-Responsive 2-DG Nanocapsules Encapsulate aV-siCPT1C Conjugates to Inhibit Glioblastoma through Multiple Inhibition of Energy Metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19285
Abstract: Aerobic glycolysis is the primary energy supply mode for glioblastoma (GBM) cells to maintain growth and proliferation. However, due to the metabolic reprogramming of tumor cells, GBM can still produce energy through fatty acid oxidation… read more here.
Keywords: energy metabolism; energy; nanocapsule; cascade responsive ... See more keywords
Tumor Microenvironment ROS/pH Cascade-Responsive Supramolecular Nanoplatform with ROS Regeneration Property for Enhanced Hepatocellular Carcinoma Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c16022
Abstract: The low targeted drug delivery efficiency, including poor tumor accumulation and penetration and uncontrolled drug release, leads to the failure of cancer therapy. Herein, a multifunctional supramolecular nanoplatform loading triptolide (TPL/PBAETK@GA NPs) was fabricated via… read more here.
Keywords: ros; supramolecular nanoplatform; therapy; hepatocellular carcinoma ... See more keywords
GSH/pH Cascade-Responsive Nanoparticles Eliminate Methicillin-Resistant Staphylococcus aureus Biofilm via Synergistic Photo-Chemo Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c17198
Abstract: Bacterial biofilm infection threatens public health, and efficient treatment strategies are urgently required. Phototherapy is a potential candidate, but it is limited because of the off-targeting property, vulnerable activity, and normal tissue damage. Herein, cascade-responsive… read more here.
Keywords: van ir780; ir780 nps; biofilm; cascade responsive ... See more keywords
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00933
Abstract: The limited therapeutic effects of immunotherapy for most types of cancer stimulates the pursuit for efficient methods to improve its response rate. Herein we report the design and synthesis of a cascade-responsive molecular prodrug for… read more here.
Keywords: molecular prodrug; chemoimmunotherapy; prodrug; cascade responsive ... See more keywords