Cascade-targeting Poly(amino acid) Nanoparticles Eliminate Intracellular Bacteria via on-site Antibiotic Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202109789
Abstract: Intracellular bacteria in latent or dormant states tolerate high-dose antibiotics. Fighting against these opportunistic bacteria has been a long-standing challenge. Herein, we design a cascade-targeting drug delivery system (DDS) that can sequentially target macrophages and… read more here.
Keywords: cascade targeting; fam nps; intracellular bacteria; rif fam ... See more keywords
Self‐Assembled Ruthenium–Amino Acid Conjugates Enable Endoplasmic Reticulum–Nucleus Cascade Targeting for Cell Pyroptosis and DNA Destruction
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202508713
Abstract: The distinct photophysical and photochemical properties of ruthenium (Ru) complexes have made them potent therapeutic agents in photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) for tumors. Simple synthesis, precise self‐assembly delivery and specific subcellular distribution… read more here.
Keywords: amino acid; cascade targeting; endoplasmic reticulum; ruthenium ... See more keywords
Lysosome-Mitochondria Cascade Targeting Nanoparticle Drives Robust Pyroptosis for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c12264
Abstract: The subcellular distribution of cargoes plays a crucial role in determining cell fate and therapeutic efficacy. However, achieving the precise delivery of therapeutics to specific intracellular targets remains a significant challenge. Here, we present a… read more here.
Keywords: cancer; pyroptosis; cascade targeting; targeting nanoparticle ... See more keywords
A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00566b
Abstract: A GLUTs/GSH cascade targeting-responsive bioprobe, GluCC, was rationally designed and synthesized for the first time via the coordination of copper ions with a glucose-modified coumarin derivative ligand (GluC). GluCC can specifically detect circulating tumor cells… read more here.
Keywords: tumor; gsh cascade; cascade targeting; detection ... See more keywords