Cascade testing for inherited arrhythmia conditions: Experiences and attitudes of family communication approaches for a Canadian cohort
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1550
Abstract: Inherited arrhythmia conditions (IAC) can lead to sudden cardiac death at any age, and relatives of an affected person have up to a 50% chance of inheriting the condition and are at risk for developing… read more here.
Keywords: arrhythmia conditions; family communication; inherited arrhythmia; approach ... See more keywords
Impact of BRCA1/2 cascade testing on anxiety, depression, and cancer worry levels among unaffected relatives in a multiethnic Asian cohort
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1619
Abstract: Cascade testing for families with BRCA pathogenic variants is important to identify relatives who are carriers. These relatives can benefit from appropriate risk management and preventative strategies arising from an inherited increased risk of breast,… read more here.
Keywords: anxiety depression; unaffected relatives; cancer worry; cascade testing ... See more keywords
Evaluation of proband adherence and satisfaction with a prospective cascade testing protocol.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.10593
Abstract: 10593 Background: We sought to evaluate the feasibility of a Cascade Testing (CT) protocol for family members of probands with actionable germline mutations associated with endometrial or ovarian cancer. Here, we characterize proband compliance with… read more here.
Keywords: probands contacted; contacted relatives; cancer; cascade testing ... See more keywords
Racial disparities in cascade testing for cancer predisposition genes.
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DOI: 10.2139/ssrn.4355742
Abstract: We sought to determine whether there are racial disparities in cascade testing rates and whether providing testing at no-charge impacts rates in Black and White at-risk-relatives (ARR). Probands with a pathogenic/likely pathogenic germline variant in… read more here.
Keywords: racial disparities; charge; disparities cascade; cancer predisposition ... See more keywords
The Impact of Proband Indication for Genetic Testing on the Uptake of Cascade Testing Among Relatives
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DOI: 10.3389/fgene.2022.867226
Abstract: Although multiple factors can influence the uptake of cascade genetic testing, the impact of proband indication has not been studied. We performed a retrospective, cross-sectional study comparing cascade genetic testing rates among relatives of probands… read more here.
Keywords: genetic testing; proactive probands; diagnostic probands; testing among ... See more keywords
Familial Hypercholesterolemia and Elevated Lipoprotein(a): Cascade Testing and Other Implications for Contextual Models of Care
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.905941
Abstract: Elevated lipoprotein(a) [Lp(a)], a predominantly genetic disorder, is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease, particularly in patients with familial hypercholesterolemia (FH), a Tier I genomic condition. The… read more here.
Keywords: models care; elevated lipoprotein; risk; cascade testing ... See more keywords
Privacy and utility of genetic testing in families with hereditary cancer syndromes living in three countries: the international cascade genetic screening experience
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1109431
Abstract: Background: Hereditary breast and ovarian cancer and Lynch syndrome are associated with increased lifetime risk for common cancers. Offering cascade genetic testing to cancer-free relatives of individuals with HBOC or LS is a public health… read more here.
Keywords: genetic testing; cascade genetic; utility; three countries ... See more keywords