Polar-Radical Cyclization Cascades with Magnesiated Nitriles.
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DOI: 10.1021/acs.orglett.3c01094
Abstract: Naphthalene converts magnesiated ω-alkenylnitriles into bi- and tricyclic ketones via a polar-radical addition-cyclization cascade. One-electron oxidation of magnesiated nitriles generates nitrile-stabilized radicals that cyclize onto a pendant olefin and then rebound onto the nitrile through… read more here.
Keywords: polar radical; radical cyclization; cyclization; cascades magnesiated ... See more keywords