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2
Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14435
Abstract: Timing by the circadian clock of Neurospora is associated with hyperphosphorylation of frequency (FRQ), which depends on anchoring casein kinase 1a (CK1a) to FRQ. It is not known how CK1a is anchored so that approximately…
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Keywords:
circadian clock;
neurospora casein;
frq;
kinase ... See more keywords
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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100497
Abstract: The quest for isoform‐selective and specific ATP‐competitive protein kinase inhibitors is of great interest, as inhibitors with these qualities will come with reduced toxicity and improved efficacy. However, creating such inhibitors is very challenging due…
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Keywords:
isopropyl pyridin;
fluorophenyl isopropyl;
casein kinase;
pyridin isoxazole ... See more keywords
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1
Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24188
Abstract: The initiation and development of thyroid cancer may be associated with the deregulation of circular RNAs (circRNAs). The purpose of this work was to explore the role of circRNA casein kinase 1 gamma 1 (circ‐CSNK1G1)…
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Keywords:
mir 149;
thyroid cancer;
casein kinase;
circrna casein ... See more keywords
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1
Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.108
Abstract: During the development of type 2 diabetes, endoplasmic reticulum (ER) stress leads to pancreatic β cell failure. CCAAT/enhancer-binding protein (C/EBP) β is highly induced by ER stress and AMP-activated protein kinase (AMPK) suppression in pancreatic…
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Keywords:
ebp pancreatic;
phosphorylates stabilizes;
stabilizes ebp;
pancreatic cells ... See more keywords
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1
Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.065
Abstract: Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in…
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Keywords:
kinase promotes;
polycystic ovary;
ovary syndrome;
casein kinase ... See more keywords
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Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.089
Abstract: SUMMARY Spt6 is a histone chaperone that associates with RNA polymerase II and deposits nucleosomes in the wake of transcription. Although Spt6 has an essential function in nucleosome deposition, it is not known whether this…
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Keywords:
spt6;
phosphorylation spt6;
casein kinase;
interaction ... See more keywords
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Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.109004
Abstract: The antimalarial drug chloroquine (CQ) induces retinopathy, a disorder characterized by lysosomotropic alteration. In this study, we examined whether D4476 (4-(4-(2,3-dihydrobenzo [1,4] dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl) benzamide), a specific casein kinase 1 inhibitor, alleviate CQ-induced retinopathy in adult…
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Keywords:
kinase inhibitor;
casein kinase;
arpe cells;
adult retinal ... See more keywords
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2
Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01180
Abstract: Specific inhibition of a single kinase isoform is a challenging task due to the highly conserved nature of ATP-binding sites. Casein kinase 1 (CK1) δ and ε share 97% sequence identity in their catalytic domains.…
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Keywords:
isoform selective;
casein kinase;
ck1;
structure ... See more keywords
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1
Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00987
Abstract: O-GlcNAc is an essential carbohydrate modification that intersects with phosphorylation signaling pathways via crosstalk on protein substrates or by direct modification of the kinases that write the phosphate modification. Casein kinase 2 alpha (CK2α), the…
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Keywords:
modification;
kinase alpha;
kinase;
casein kinase ... See more keywords
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1
Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0515-6
Abstract: Glioma is a devastating cancer with a dismal prognosis and there is an urgent need to discover novel glioma-specific antigens for glioma therapy. Previous studies have identified CD163-positive tumour cells in certain solid tumours, but…
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Keywords:
glioma;
cd163;
glioma cells;
casein kinase ... See more keywords
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Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0927-y
Abstract: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is…
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Keywords:
inhibition;
expression;
casein kinase;
tmz ... See more keywords