Tamarixetin Attenuated the Virulence of Staphylococcus aureus by Directly Targeting Caseinolytic Protease P.
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DOI: 10.1021/acs.jnatprod.2c00138
Abstract: Staphylococcus aureus, especially drug-resistant S. aureus infections, is a worldwide healthcare challenge. There is a growing focus on antivirulence therapy against S. aureus. Caseinolytic protease p (ClpP) is a protein hydrolase essential for pathogenicity in… read more here.
Keywords: staphylococcus aureus; tamarixetin; clpp; caseinolytic protease ... See more keywords
Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential
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DOI: 10.3389/fmolb.2021.690902
Abstract: Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it… read more here.
Keywords: mechanism; caseinolytic protease; reprogramming caseinolytic; adep ... See more keywords
Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide
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DOI: 10.3390/molecules27123787
Abstract: The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal… read more here.
Keywords: catalytic properties; inhibition; lactone; member ... See more keywords