Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters
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DOI: 10.1128/cmr.00159-19
Abstract: Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open cavities connecting with an airway. Several commonly accepted characteristics of caseum… read more here.
Keywords: mycobacterium tuberculosis; drug; tuberculosis; oxygen tension ... See more keywords
A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
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DOI: 10.1128/mbio.00598-23
Abstract: M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have… read more here.
Keywords: tuberculosis; caseum; mtb; drug tolerant ... See more keywords