Notch inhibition counteracts Paneth cell death in absence of caspase-8
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DOI: 10.1007/s00428-018-2368-3
Abstract: Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly… read more here.
Keywords: paneth cell; inhibition; notch; casp8 int ... See more keywords