Caspase 3‐specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress‐induced apoptosis
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DOI: 10.1002/2211-5463.13574
Abstract: Proper regulation of apoptotic cell death is crucial for normal development and homeostasis in multicellular organisms and is achieved by the balance between pro‐apoptotic processes, such as caspase activation, and pro‐survival signaling, such as extracellular… read more here.
Keywords: apoptosis; stress induced; erk; mek1 ... See more keywords
Knockout of Sf‐Caspase‐1 generates apoptosis‐resistant Sf9 cell lines: Implications for baculovirus expression
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DOI: 10.1002/biot.202100532
Abstract: The Sf9 cell line, originally isolated from the insect Spodoptera frugiperda, is commonly used alongside the baculovirus expression vector system (BEVS) to produce recombinant proteins and other biologics. As more BEVS‐derived vaccines and therapeutics are… read more here.
Keywords: cell; caspase; sf9 cell; baculovirus expression ... See more keywords
Apoptotic susceptibility of pancreatic alpha cells to environmentally relevant dose levels of bisphenol‐A versus dibutyl phthalate is mediated by HSP60/caspase‐3 expression in male albino rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11909
Abstract: Unfortunately, humanity is exposed to mixed plasticizers such as bisphenol‐A (BPA) and dibutyl phthalate (DBP) that are leached from the daily used plastic products. Previous studies have demonstrated their potential in pancreatic beta cell injury… read more here.
Keywords: pancreatic alpha; dibutyl phthalate; hsp60 caspase; expression ... See more keywords
Septins promote caspase activity and coordinate mitochondrial apoptosis.
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DOI: 10.1002/cm.21696
Abstract: Apoptosis is a form of regulated cell death essential for embryonic development and tissue homeostasis. Apoptosis also plays key roles during bacterial infection, yet some intracellular bacterial pathogens (such as Shigella flexneri, whose lipopolysaccharide can… read more here.
Keywords: mitochondrial apoptosis; caspase; infection; flexneri ... See more keywords
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells
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DOI: 10.1002/ddr.21939
Abstract: Secoisolariciresinol diglucoside (SDG) is the main component of lignans with various biological activities, including anticancer activity. However, whether SDG has obvious anticancer effects on colorectal cancer (CRC) is unclear. Pyroptosis, a form of programmed cell… read more here.
Keywords: sdg; pyroptosis; secoisolariciresinol diglucoside; colorectal cancer ... See more keywords
Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells
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DOI: 10.1002/ijc.31374
Abstract: Caspase‐3 (CASP3) is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy or immunotherapy. It is often used as a marker for efficacy of cancer therapy. However, recent reports indicate that… read more here.
Keywords: cancer; caspase; invasion metastasis; colon cancer ... See more keywords
The Synergic Inhibition of Wilforlide A With Cisplatin in Lung Cancer Is Mediated Through Caspase‐3 and NFκB Signaling
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DOI: 10.1002/iub.70043
Abstract: Lung cancer is a malignant disease in the respiratory system and accounts for hundreds of thousands of deaths each year. Cisplatin is the first‐line drug in the clinic for lung cancer. However, drug resistance and… read more here.
Keywords: synergic inhibition; cancer; cisplatin; lung cancer ... See more keywords
Quercetin plays protective role in oxidative induced apoptotic events during chronic chlorpyrifos exposure to rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22341
Abstract: Chlorpyrifos (CPF), an organophosphate insecticide has a wider application throughout the world to protect agricultural crops and vegetables from insects. Polyphenolic compounds are considered as beneficial against toxicities induced by organophosphates. The present study was… read more here.
Keywords: chlorpyrifos; caspase; apoptotic events; quercetin ... See more keywords
Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23622
Abstract: Chronic tobacco use can lead to liver damage and inflammation due to the accumulation of various toxins in the body. This study aimed to investigate the correlation between the molecular mechanisms of nicotine‐induced liver injury,… read more here.
Keywords: bcl caspase; nicotine induced; bax bcl; caspase ... See more keywords
Development of 1,2,3‐Triazolopyridazinone Derivatives as Potential Caspase 3 and Apoptosis Inducers: Design, Synthesis and Anticancer Activity Studies
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70216
Abstract: Herein, the synthesis, anticancer activity and apoptotic pathways of 1,2,3‐triazolopyridazinones compounds, which are similar to DNA bases not previously found in the literature have been investigated. To achieve this goal, it is designed the hybrid… read more here.
Keywords: synthesis anticancer; anticancer activity; caspase; apoptosis ... See more keywords
Tomentosin Induces Telomere Shortening and Caspase‐Dependant Apoptosis in Cervical Cancer Cells
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DOI: 10.1002/jcb.25826
Abstract: Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti‐proliferative, telomere shortening, and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit… read more here.
Keywords: caspase; telomere shortening; apoptosis; cervical cancer ... See more keywords