Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase‐8 activation
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000448
Abstract: Continuing our studies on NO‐donating ursolic acid–benzylidene derivatives as potential antitumor agents, we designed and synthesized a series of new arylidene derivatives containing NO‐donating ursolic acid and aromatic heterocyclic units. Compounds 5c and 6c showed… read more here.
Keywords: new arylidene; ursolic acid; caspase activation;
Phosphoinositide‐3 kinase gamma regulates caspase‐1 activation and leukocyte recruitment in acute murine gout
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.ma1118-470rr
Abstract: This study investigates the participation of PI3Kγ in the development of joint inflammation and dysfunction in an experimental model of acute gout in mice. Acute gout was induced by injection of monosodium urate (MSU) crystals… read more here.
Keywords: caspase activation; gout; msu; pi3k ... See more keywords
Early genetic restoration of lubricin expression in transgenic mice mitigates chondrocyte peroxynitrite release and caspase-3 activation.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.05.012
Abstract: OBJECTIVE This study investigated the ability of endogenous lubricin secretion to restore joint health following a brief read more here.
Keywords: caspase; caspase activation; mice; lubricin ... See more keywords
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.167
Abstract: Caspase-4 is an inflammatory caspase; however, its mechanism of activation is poorly understood. In this study, we demonstrate that Td92, a surface protein of the periodontal pathogen Treponema denticola and a homolog of the Treponema… read more here.
Keywords: caspase activation; surface protein; td92; activation ... See more keywords
Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42298-4
Abstract: Unconventional protein secretion represents an important process of the inflammatory response. The release of the pro-inflammatory cytokine interleukin (IL)-1β which burst during pyroptosis as a consequence of gasdermin D plasma membrane pore formation, can also… read more here.
Keywords: caspase; caspase activation; early endosome; endosome autoantigen ... See more keywords
Fish-Oil-Derived DHA-mediated Enhancement of Apoptosis in Acute Lymphoblastic Leukemia Cells is Associated with Accumulation of p53, Downregulation of Survivin, and Caspase-3 Activation
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2017.1247884
Abstract: ABSTRACT In acute lymphoblastic leukemia (ALL), resistance to chemotherapy is associated with inactivation of p53 and upregulation of survivin. Thus, targeting the p53 and survivin expression may provide an attractive strategy for ALL treatment. It… read more here.
Keywords: caspase activation; survivin; dha; p53 ... See more keywords
Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-08-0387
Abstract: Pannexins (PANX) are a family of three channel-forming membrane glycoproteins expressed in the skin. Previous studies have focused on the role of PANX1 and PANX3 in the regulation of cellular functions in skin cells while… read more here.
Keywords: skin; pannexin expressed; caspase activation; uvb induced ... See more keywords
F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-04-0119
Abstract: The actin cytoskeleton is a ubiquitous participant in cellular functions that maintain viability, but how it controls programmed cell death is not well understood. Here we show that in response to DNA damage, human cells… read more here.
Keywords: dna damage; caspase activation; caspase; actin rich ... See more keywords
Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12756
Abstract: Inflammasomes are innate immune mechanisms that activate caspase‐1 in response to a variety of stimuli, including Salmonella infection. Active caspase‐1 has a potential to induce two different types of cell death, depending on the expression… read more here.
Keywords: caspase; caspase activation; apoptosis; caspase induced ... See more keywords
Mitochondrial toxicity and caspase activation in HIV pregnant women
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.12935
Abstract: To assess the impact of HIV‐infection and highly active anti‐retroviral treatment in mitochondria and apoptotic activation of caspases during pregnancy and their association with adverse perinatal outcome. Changes of mitochondrial parameters and apoptotic caspase activation… read more here.
Keywords: activation hiv; caspase activation; pregnant women; activation ... See more keywords
Tetraacetyl Riboflavin Derivative Mediates Caspase 3/7 Activation via MAPK in A431 Cells upon Blue Light Influence.
Sign Up to like & getrecommendations! Published in 2023 at "Photochemistry and photobiology"
DOI: 10.1111/php.13806
Abstract: An acetylated riboflavin derivative, 3-methyl-tetraacetyl riboflavin (3MeTARF), is a compound with high photostability and photophysical properties similar to riboflavin, including the ability to photogenerate singlet oxygen. In the present study, we compared the effects of… read more here.
Keywords: riboflavin derivative; caspase activation; tetraacetyl riboflavin; riboflavin ... See more keywords