Inflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Neurocritical Care"
DOI: 10.1007/s12028-020-01113-z
Abstract: Subarachnoid hemorrhage (SAH) is a devastating neurological injury, further complicated by few available methods to objectively predict outcomes. With the recent shift in focus to neuroinflammation as a potential cause of adverse outcomes following SAH,… read more here.
Keywords: caspase activity; caspase; functional outcome; sah ... See more keywords
Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2022.03.003
Abstract: Residential and occupational exposures to the industrial solvents perchloroethylene (PERC) and trichloroethylene (TCE) present public health concerns. In humans, maternal PERC and TCE exposures can be associated with adverse birth outcomes. Because PERC and TCE… read more here.
Keywords: caspase activity; perc tce; three vitro; htr svneo ... See more keywords
Determination of Caspase-3 Activity and Its Inhibition Constant by Combination of Fluorescence Correlation Spectroscopy with a Microwell Chip.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01735
Abstract: Caspase-3 is a key enzyme executing apoptosis during ontogenesis and homeostasis of multicellular organisms, and is a very important and potential drug target in treatment of apoptosis disturbance. So far, no commercial drugs for caspase-3… read more here.
Keywords: caspase; caspase activity; determination; method ... See more keywords
Super-Sensitive Chemiluminescent Probe for the Detection of Caspase‑3 Activity
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.5c00151
Abstract: Caspase-3 is a pivotal enzyme in the apoptosis pathway that is responsible for executing programmed cell death through the cleavage of key cellular proteins. Existing fluorescence-based probes for caspase-3 detection suffer from limitations such as… read more here.
Keywords: detection; chemiluminescent; caspase activity; caspase ... See more keywords
Label-free and amplified detection of apoptosis-associated caspase activity using branched rolling circle amplification.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc01564d
Abstract: We develop a label-free fluorescence method for ultrasensitive detection of apoptosis-associated caspase activity based on branched rolling circle amplification. This work demonstrates for the first time the use of a nucleic acid amplification strategy for… read more here.
Keywords: caspase; detection; caspase activity; label free ... See more keywords
Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc07821b
Abstract: Caspase-3/8 are key members of the cysteine-aspartyl protease family with pivotal roles in apoptosis. We have designed and synthesized self-assembling probes, Nap-GFFpYDEVD-AFC and Nap-GFFpYIETD-AFC, with fluorescence 'turn-on' properties for real-time monitoring of Caspase-3/8 activity in… read more here.
Keywords: caspase; time monitoring; self assembling; real time ... See more keywords
GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjy056
Abstract: Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce… read more here.
Keywords: gsdmb promotes; gsdmb; caspase activity; canonical pyroptosis ... See more keywords
TMEM16A regulates satellite cell mediated skeletal muscle regeneration by ensuring a moderate level of caspase 3 activity.
Sign Up to like & getrecommendations! Published in 2024 at "Stem cells"
DOI: 10.1093/stmcls/sxae048
Abstract: It has been documented that caspase 3 activity is necessary for skeletal muscle regeneration, but how its activity is regulated is largely unknown. Our previous report shows that intracellular TMEM16A, a calcium activated chloride channel,… read more here.
Keywords: skeletal muscle; caspase activity; regeneration; activity ... See more keywords
A novel thrombocytopenia‐4‐causing CYCS gene variant decreases caspase activity: Three‐generation study
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Haematology"
DOI: 10.1111/bjh.19694
Abstract: The CYCS gene is highly evolutionarily conserved, with only a few pathogenic variants that cause thrombocytopenia‐4 (THC4). Here, we report a novel CYCS variant NM_018947.6: c.59C>T [NP_061820.1:p.(Thr20Ile)] segregating with thrombocytopenia in three generations of a… read more here.
Keywords: gene; cycs gene; caspase activity; thrombocytopenia ... See more keywords
Abstract TMP23: Inflammasome-derived Caspase-1 is Elevated in the Cerebrospinal Fluid of Subarachnoid Hemorrhage Patients and Correlated to Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tmp23
Abstract: Introduction: The role of neuroinflammation following aneurysmal subarachnoid hemorrhage (SAH) and its relationship to outcome is the subject of many ongoing studies. The proteolytic enzyme, caspase-1, activated by the inflammasome complex, is known to contribute… read more here.
Keywords: cerebrospinal fluid; outcome; caspase; activity ... See more keywords
Interleukin-1 receptor-dependent and -independent caspase-1 activity in retinal cells mediated by receptor interacting protein 2
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1467799
Abstract: Introduction Inflammation and cell death play an important role in the pathogenesis of diabetic retinopathy. Previously we observed sustained activation of pro-inflammatory caspase-1 in retinas of diabetic animals and patients. In this study, we aimed… read more here.
Keywords: caspase; caspase activation; caspase activity; receptor ... See more keywords