Inflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Neurocritical Care"
DOI: 10.1007/s12028-020-01113-z
Abstract: Subarachnoid hemorrhage (SAH) is a devastating neurological injury, further complicated by few available methods to objectively predict outcomes. With the recent shift in focus to neuroinflammation as a potential cause of adverse outcomes following SAH,… read more here.
Keywords: caspase activity; caspase; functional outcome; sah ... See more keywords
Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2022.03.003
Abstract: Residential and occupational exposures to the industrial solvents perchloroethylene (PERC) and trichloroethylene (TCE) present public health concerns. In humans, maternal PERC and TCE exposures can be associated with adverse birth outcomes. Because PERC and TCE… read more here.
Keywords: caspase activity; perc tce; three vitro; htr svneo ... See more keywords
Determination of Caspase-3 Activity and Its Inhibition Constant by Combination of Fluorescence Correlation Spectroscopy with a Microwell Chip.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01735
Abstract: Caspase-3 is a key enzyme executing apoptosis during ontogenesis and homeostasis of multicellular organisms, and is a very important and potential drug target in treatment of apoptosis disturbance. So far, no commercial drugs for caspase-3… read more here.
Keywords: caspase; caspase activity; determination; method ... See more keywords
Label-free and amplified detection of apoptosis-associated caspase activity using branched rolling circle amplification.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc01564d
Abstract: We develop a label-free fluorescence method for ultrasensitive detection of apoptosis-associated caspase activity based on branched rolling circle amplification. This work demonstrates for the first time the use of a nucleic acid amplification strategy for… read more here.
Keywords: caspase; detection; caspase activity; label free ... See more keywords
Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc07821b
Abstract: Caspase-3/8 are key members of the cysteine-aspartyl protease family with pivotal roles in apoptosis. We have designed and synthesized self-assembling probes, Nap-GFFpYDEVD-AFC and Nap-GFFpYIETD-AFC, with fluorescence 'turn-on' properties for real-time monitoring of Caspase-3/8 activity in… read more here.
Keywords: caspase; time monitoring; self assembling; real time ... See more keywords
GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjy056
Abstract: Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce… read more here.
Keywords: gsdmb promotes; gsdmb; caspase activity; canonical pyroptosis ... See more keywords
Abstract TMP23: Inflammasome-derived Caspase-1 is Elevated in the Cerebrospinal Fluid of Subarachnoid Hemorrhage Patients and Correlated to Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tmp23
Abstract: Introduction: The role of neuroinflammation following aneurysmal subarachnoid hemorrhage (SAH) and its relationship to outcome is the subject of many ongoing studies. The proteolytic enzyme, caspase-1, activated by the inflammasome complex, is known to contribute… read more here.
Keywords: cerebrospinal fluid; outcome; caspase; activity ... See more keywords
Inhibition of Apoptotic Pathways Improves DNA Integrity but Not Developmental Competence of Domestic Cat Immature Vitrified Oocytes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.588334
Abstract: Being a model for endangered wild felids, cryopreservation protocols for domestic cat oocytes are under continuous development. Immature vitrified oocytes (VOs) are a valuable resource for fertility preservation programs, but they often degenerate after warming… read more here.
Keywords: caspase; caspase activity; cat; vad fmk ... See more keywords
Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073318
Abstract: Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning has been changed by findings of its… read more here.
Keywords: caspase; regulation caspase; caspase activity; inflammation ... See more keywords