Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.10.028
Abstract: Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to… read more here.
Keywords: caspase; death; aim2 inflammasome; cleavage ... See more keywords
Rescue of Infectious Recombinant Hazara Nairovirus from cDNA Reveals the Nucleocapsid Protein DQVD Caspase Cleavage Motif Performs an Essential Role other than Cleavage
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00616-19
Abstract: HAZV is classified within the Nairoviridae family with CCHFV, which is one of the most lethal human pathogens in existence, requiring the highest biosafety level (BSL) containment (BSL4). In contrast, HAZV is not associated with… read more here.
Keywords: cleavage; system; role; hazv ... See more keywords
Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1086112
Abstract: Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is… read more here.
Keywords: full length; huntingtin; caspase cleavage; huntingtin palmitoylated ... See more keywords