Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0104-9
Abstract: Deletion of the Casp8 gene in epithelial tissues of mice results in severe inflammatory pathologies. Its ubiquitous deletion, or its specific deletion in endothelial cells, results in intrauterine death associated with capillary damage. These pathologies… read more here.
Keywords: deletion; inflammatory genes; activation inflammatory; caspase deficiency ... See more keywords
Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1113883
Abstract: Introduction Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges from simple steatosis (non-alcoholic fatty liver) to non-alcoholic… read more here.
Keywords: induced nafld; pyroptosis; high fat; caspase deficiency ... See more keywords