Involvement of NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis in BPA-Induced Apoptosis of Human Neuroblastoma Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115042
Abstract: Bisphenol A (BPA) induces neurotoxicity via enhancing cell apoptosis and inflammation potently (effective at nanomolar concentrations), but its mechanisms remain unidentified. In this study, human neuroblastoma cell lines, IMR-32 and SK-N-SH cells, isolated from a… read more here.
Keywords: caspase gsdmd; nlrp3 caspase; caspase; apoptosis ... See more keywords
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2098764
Abstract: Abstract Acute kidney injury (AKI) is a serious condition with high mortality. The most common cause is kidney ischemia/reperfusion (IR) injury, which is thought to be closely related to pyroptosis. Disulfiram is a well-known alcohol… read more here.
Keywords: injury; pyroptosis; disulfiram; caspase gsdmd ... See more keywords
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1773860
Abstract: Septic encephalopathy (SE) is a devastating consequence of sepsis, a hyper-triggered host response against infectious challenge, which ultimately leads to brain damage. The present study examined whether sevoflurane (SVF), a volatile anaesthetic, can counteract the… read more here.
Keywords: sirt1; caspase gsdmd; sepsis; model ... See more keywords
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats
Sign Up to like & getrecommendations! Published in 2022 at "Electromagnetic Biology and Medicine"
DOI: 10.1080/15368378.2021.2021933
Abstract: ABSTRACT Low-grade inflammation is a key mediator of the pathogenesis of Osteoarthritis (OA). Pulsed electromagnetic field (PEMF) can improve the symptoms of OA and potentially acts as an anti-inflammatory. The aim of this study was… read more here.
Keywords: nlrp3 caspase; gsdmd signaling; caspase gsdmd; pemf ... See more keywords
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages
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DOI: 10.1155/2022/8123157
Abstract: Objectives Although a recent study reported that stimulator of interferon genes (STING) in macrophages has an important regulatory effect on liver ischemia-reperfusion injury (IRI), the underlying mechanism of STING-dependent innate immune activation in liver macrophages… read more here.
Keywords: calcium; liver; caspase gsdmd; microscopy ... See more keywords
Hydrogen Sulfide Attenuates Neuroinflammation by Inhibiting the NLRP3/Caspase-1/GSDMD Pathway in Retina or Brain Neuron following Rat Ischemia/Reperfusion
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DOI: 10.3390/brainsci12091245
Abstract: Gasdermin D-executing pyroptosis mediated by NLRP3 inflammasomes has been recognized as a key pathogenesis during stroke. Hydrogen sulfide (H2S) could protect CNS against ischemia/reperfusion (I/R)-induced neuroinflammation, while the underlying mechanism remains unclear. The study applied… read more here.
Keywords: hydrogen sulfide; nlrp3 caspase; brain; caspase gsdmd ... See more keywords