Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107496
Abstract: OBJECTIVES Cathepsin B (CTSB), nod-like receptor family pyrin domain-containing 3 (NLRP3), and caspase-1 play an important role in the development of Acute Pancreatitis (AP). Besides, the relationship between the proteins remains poorly understood. In addition,… read more here.
Keywords: acute pancreatitis; caspase; pyroptosis; activating nlrp3 ... See more keywords
Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12756
Abstract: Inflammasomes are innate immune mechanisms that activate caspase‐1 in response to a variety of stimuli, including Salmonella infection. Active caspase‐1 has a potential to induce two different types of cell death, depending on the expression… read more here.
Keywords: caspase; caspase activation; apoptosis; caspase induced ... See more keywords