Pterostilbene inhibits amyloid‐β‐induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase‐1 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27023
Abstract: Neuroinflammation has been known as an important pathogenetic contributor of Alzheimer's disease (AD). Pterostilbene is a natural compound which has neuroprotective activity. However, the effect of pterostilbene on amyloid‐β (Aβ)‐induced neuroinflammation has not been clarified.… read more here.
Keywords: nlrp3 caspase; caspase inflammasome; neuroinflammation; induced neuroinflammation ... See more keywords
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav5562
Abstract: Targeting immunometabolism is a strategy to prevent infection-mediated septic death. The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11–dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about… read more here.
Keywords: camp; inflammasome activation; caspase inflammasome; activation pyroptosis ... See more keywords
AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01904
Abstract: Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic… read more here.
Keywords: sepsis; inflammasome activation; caspase inflammasome; ager mediated ... See more keywords
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.755961
Abstract: Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage. Factors that promote non-canonical inflammasome activation are well recognized,… read more here.
Keywords: antibacterial immunity; inflammasome activation; caspase inflammasome; caspase ... See more keywords
Caspase-1 and the inflammasome promote polycystic kidney disease progression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.971219
Abstract: We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of… read more here.
Keywords: disease; progression; caspase inflammasome; disease progression ... See more keywords