The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway
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DOI: 10.1007/s10557-018-6781-2
Abstract: PurposeProtecting the heart from ischaemia-reperfusion (IR) injury is a major goal in patients presenting with an acute myocardial infarction. Pyroptosis is a novel form of cell death in which caspase 1 is activated and cleaves… read more here.
Keywords: caspase; caspase inhibitor; inhibitor; heart ... See more keywords
Caspase inhibitors: a review of recently patented compounds (2013-2015)
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DOI: 10.1080/13543776.2017.1378426
Abstract: ABSTRACT Introduction: Although many caspase inhibitors have been patented, caspase inhibitors have not entered the market due to their toxicity and poor pharmacokinetic profile. Areas covered: In this article, we review patents (2013–2015) for peptide… read more here.
Keywords: 2013 2015; caspase inhibitor; caspase; review recently ... See more keywords
Application of the Movable Type Free Energy Method to the Caspase-Inhibitor Binding Affinity Study
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DOI: 10.3390/ijms20194850
Abstract: Many studies have provided evidence suggesting that caspases not only contribute to the neurodegeneration associated with Alzheimer’s disease (AD) but also play essential roles in promoting the underlying pathology of this disease. Studies regarding the… read more here.
Keywords: caspase; caspase inhibitor; inhibitor; method ... See more keywords