Antiapoptotic effects of caspase inhibitors on H2O2-treated lung cancer cells concerning oxidative stress and GSH
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3179-6
Abstract: Exogenous hydrogen peroxide (H2O2) induces oxidative stress and apoptosis in cancer cells. This study evaluated the antiapoptotic effects of pan-caspase and caspase-3, -8, or -9 inhibitors on H2O2-treated Calu-6 and A549 lung cancer cells in… read more here.
Keywords: h2o2 treated; gsh; h2o2; caspase inhibitors ... See more keywords
Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.019
Abstract: Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here… read more here.
Keywords: design synthesis; diaminopyrimidine derivatives; evaluation diaminopyrimidine; structure based ... See more keywords
Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.001
Abstract: Caspases control regulated cell death (apoptosis), a process that is crucial in the development of multicellular organisms as well as in various diseases. In order to spatiotemporally study apoptosis, we here develop photoactivatable caspase inhibitors.… read more here.
Keywords: photoactivatable caspase; apoptosis; controlled inhibition; caspase inhibitors ... See more keywords
Caspase inhibitors: a review of recently patented compounds (2013-2015)
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1378426
Abstract: ABSTRACT Introduction: Although many caspase inhibitors have been patented, caspase inhibitors have not entered the market due to their toxicity and poor pharmacokinetic profile. Areas covered: In this article, we review patents (2013–2015) for peptide… read more here.
Keywords: 2013 2015; caspase inhibitor; caspase; review recently ... See more keywords
The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144587
Abstract: Propyl gallate [3,4,5-trihydroxybenzoic acid propyl ester; PG] exhibits an anti-growth effect in various cells. In this study, the anti-apoptotic effects of various caspase inhibitors were evaluated in PG-treated Calu-6 and A549 lung cancer cells in… read more here.
Keywords: lung cancer; caspase inhibitors; anti apoptotic; lung ... See more keywords
De Novo Molecular Design of Caspase-6 Inhibitors by a GRU-Based Recurrent Neural Network Combined with a Transfer Learning Approach
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14121249
Abstract: Due to their potential in the treatment of neurodegenerative diseases, caspase-6 inhibitors have attracted widespread attention. However, the existing caspase-6 inhibitors showed more or less inevitable deficiencies that restrict their clinical development and applications. Therefore,… read more here.
Keywords: caspase inhibitors; caspase; recurrent neural; gru based ... See more keywords