Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01986-z
Abstract: The antiproliferative effect of cardamonin on mTORC1 is related with downregulation of Raptor. We investigated the mechanism that cardamonin decreases Raptor expression through caspase-mediated protein degradation. SKOV3 cells and HeLa cells were pretreated with caspase… read more here.
Keywords: cardamonin; caspase; caspase mediated; cleavage ... See more keywords
Lysionotin Induces Apoptosis of Hepatocellular Carcinoma Cells via Caspase-3 Mediated Mitochondrial Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109500
Abstract: As the sixth most prevalent cancer, liver cancer has been reported as the second cause of cancer-induced deaths globally. Lysionotin, a flavonoid compound widely distributed in Lysionotus pauciflorus Maxim, has attracted considerable attention due to… read more here.
Keywords: caspase; mediated mitochondrial; caspase mediated; apoptosis ... See more keywords
Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105771
Abstract: OBJECTIVE Intracerebral hemorrhage (ICH) is acknowledged as a serious clinical problem lacking effective treatments. And caspase-1-mediated inflammatory response happened during the progression of ICH. Therefore, we aimed to investigate the effects of caspase-1 inhibitor Ac-YVAD-cmk… read more here.
Keywords: caspase; yvad cmk; caspase mediated; intracerebral hemorrhage ... See more keywords
Polychlorinated Biphenyl Quinone Induces Caspase 1-Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.8b00376
Abstract: Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated… read more here.
Keywords: hmgb1; pcb29; caspase mediated; pyroptosis ... See more keywords
Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12663
Abstract: Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin… read more here.
Keywords: caspase mediated; mouse macrophages; cisplatin doxorubicin; secondary necrosis ... See more keywords
Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.585146
Abstract: The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial cells… read more here.
Keywords: tlr4 caspase; caspase; caspase mediated; tlr4 complex ... See more keywords
The Therapeutic Potential of Pyroptosis in Melanoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021285
Abstract: Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far, including the… read more here.
Keywords: therapeutic potential; caspase mediated; pyroptosis; potential pyroptosis ... See more keywords
Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076662
Abstract: Compound 6d, a spiroindoline compound, exhibits antiproliferative capability against cancer cell lines. However, the exact underlying mechanism of this compound-mediated inhibitory capability remains unclear. Here, we showed that compound 6d is an inhibitor of Bcl-2,… read more here.
Keywords: compound; caspase mediated; hdac6; cancer ... See more keywords
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11629
Abstract: Human cathelicidin antimicrobial peptide and its active product, LL-37 (CAMP/LL-37), exhibit a broad spectrum of antimicrobial effects. An increasing number of studies have shown that human CAMP/LL-37 also serves significant roles in various types of… read more here.
Keywords: camp; caspase mediated; expression; mediated apoptosis ... See more keywords
Long noncoding RNA X-inactive specific transcript regulates NLR family pyrin domain containing 3/caspase-1-mediated pyroptosis in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Diabetes"
DOI: 10.4239/wjd.v13.i4.358
Abstract: BACKGROUND NLRP3-mediated pyroptosis is recognized as an essential modulator of renal disease pathology. Long noncoding RNAs (lncRNAs) are active participators of diabetic nephropathy (DN). X inactive specific transcript (XIST) expression has been reported to be… read more here.
Keywords: caspase mediated; silencing xist; pyroptosis; xist ... See more keywords
Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.47084
Abstract: Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in… read more here.
Keywords: cleavage; endoplasmic reticulum; caspase mediated; caspase ... See more keywords