Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans.
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DOI: 10.1007/s00294-020-01105-8
Abstract: The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidiasis. Signaling pathways… read more here.
Keywords: wall damage; caspofungin; candida albicans; caspofungin induced ... See more keywords
Caspofungin induces the release of Ca2+ ions from internal stores by activating ryanodine receptor-dependent pathways in human tracheal epithelial cells
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DOI: 10.1038/s41598-020-68626-7
Abstract: The antimycotic drug caspofungin is known to alter the cell function of cardiomyocytes and the cilia-bearing cells of the tracheal epithelium. The objective of this study was to investigate the homeostasis of intracellular Ca2+ concentration… read more here.
Keywords: epithelial cells; caspofungin; human tracheal; ca2 ... See more keywords
Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes
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DOI: 10.1080/21505594.2021.1927609
Abstract: ABSTRACT Candida auris has emerged as a fungal pathogen that causes nosocomial outbreaks worldwide. Diseases caused by this fungus are of concern, due to its reduced susceptibility to several antifungals. C. auris exhibits paradoxical growth… read more here.
Keywords: cell wall; cpf; candida auris; caspofungin ... See more keywords
Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata
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DOI: 10.1093/jac/dkab454
Abstract: Abstract Background Echinocandin resistance represents a great concern, as these drugs are recommended as first-line therapy for invasive candidiasis. Echinocandin resistance is conferred by mutations in FKS genes. Nevertheless, pathways are crucial for enabling tolerance,… read more here.
Keywords: response; caspofungin; response caspofungin; resistance ... See more keywords
Caspofungin dosage adjustments are not required for patients with Child–Pugh B or C cirrhosis
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DOI: 10.1093/jac/dky189
Abstract: Background Controversies remain over caspofungin dosage adjustments in cirrhosis, particularly Child-Pugh (CP) B or C. The product information for of caspofungin recommends a maintenance dose reduction from 50 to 35 mg for patients with CP-B cirrhosis.… read more here.
Keywords: caspofungin; cirrhosis; dosage adjustments; caspofungin dosage ... See more keywords
Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections
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DOI: 10.1111/jcpt.13026
Abstract: Caspofungin is commonly used in kidney transplant patients for prophylaxis or treatment of invasive fungal infections (IFIs) caused by Candida spp. and Aspergillus spp. Factors such as concomitant medications, co‐morbidity and rejection often cause caspofungin… read more here.
Keywords: transplant patients; kidney transplant; caspofungin; fungal infections ... See more keywords
Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin
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DOI: 10.1128/aac.01159-18
Abstract: The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective against Pneumocystis asci. ABSTRACT The echinocandin… read more here.
Keywords: pneumocystis; caspofungin; sensitivity caspofungin; catalytic subunit ... See more keywords
Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata
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DOI: 10.1128/aac.01692-18
Abstract: Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in Candida mutational frequency of resistance or propensity to develop FKS mutations. ABSTRACT Echinocandins are front-line agents for treatment of… read more here.
Keywords: micafungin; fks mutation; caspofungin; mutational frequency ... See more keywords
Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development
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DOI: 10.1128/spectrum.00439-22
Abstract: The authors have developed a lead compound peptide antifungal drug targeting a protein from the organism Cryptococcus neoformans. Binding of the drug to the target fungal protein causes charged lipid molecules to be retained on… read more here.
Keywords: development; lead compound; caspofungin; drug ... See more keywords
Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus
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DOI: 10.1128/spectrum.00519-22
Abstract: This is one of the first studies to apply genomewide association (GWA) analysis to identify genes involved in an Aspergillus fumigatus phenotype. A. fumigatus is an opportunistic fungal pathogen that causes hundreds of thousands of… read more here.
Keywords: aspergillus fumigatus; paradoxical effect; caspofungin paradoxical; cpe ... See more keywords
Plasma concentrations of caspofungin in a critically ill patient with morbid obesity
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DOI: 10.1186/s13054-017-1774-2
Abstract: The aim of the study was to describe the pharmacokinetic behaviour of caspofungin in a critically ill patient with morbid obesity who received doses of caspofungin higher than labelled doses. A 57-year-old morbidly obese man… read more here.
Keywords: ill patient; caspofungin; critically ill; caspofungin critically ... See more keywords