Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex
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DOI: 10.1002/ana.26345
Abstract: The encephalitis associated with antibodies against contactin‐associated proteinlike 2 (CASPR2) is presumably antibody‐mediated, but the antibody effects and whether they cause behavioral alterations are not well known. Here, we used a mouse model of patients'… read more here.
Keywords: alter memory; antibodies reversibly; caspr2; caspr2 antibodies ... See more keywords
Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero
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DOI: 10.1007/s00401-017-1751-5
Abstract: Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recently reported a fivefold increase in CASPR2-antibodies in mid-gestation sera… read more here.
Keywords: igg exposed; caspr2 igg; persistent microglial; caspr2 ... See more keywords
Distinct HLA associations of LGI1 and CASPR2-antibody diseases
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DOI: 10.1093/brain/awy109
Abstract: The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations, most significantly in HLA-DRB1*07:01 for LGI1, and HLA-DRB1*11:01 for CASPR2. Prediction of antigen-specific HLA-binding peptides… read more here.
Keywords: distinct hla; lgi1 caspr2; associations lgi1; hla ... See more keywords
Clinical Character of CASPR2 Autoimmune Encephalitis: A Multiple Center Retrospective Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.652864
Abstract: Objective To examine the clinical characteristics of autoimmune encephalitis associated with the contactin-associated protein-2 (CASPR2) antibody. Materials and Methods Medical records of all patients diagnosed with CASPR2 antibody-associated encephalitis were retrospectively analysed. Data regarding demographic… read more here.
Keywords: autoimmune encephalitis; eight patients; antibody; study ... See more keywords
Clinical spectrum of contactin-associated protein 2 autoimmune encephalitis in children
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DOI: 10.3389/fnins.2023.1106214
Abstract: Objective Anti-contactin-associated protein 2 (CASPR2)-related autoimmune encephalitis (AE) is more common in adults than in children. Clinical understanding of anti-CASPR2-antibody (Ab)-related AE, diagnosis and treatment standards are lacking in children. Therefore, this retrospective study on… read more here.
Keywords: caspr2 related; anti caspr2; caspr2; associated protein ... See more keywords
Phenotypic Spectrum of CASPR2 and LGI1 Antibodies Associated Neurological Disorders in Children
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DOI: 10.3389/fped.2022.815976
Abstract: Objectives The clinical data of patients with double-positive for leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies is limited, particularly for children. This study aimed to investigate and summarize the clinical features… read more here.
Keywords: lgi1 antibodies; caspr2 lgi1; ivig ivmp; caspr2 ... See more keywords