Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex
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DOI: 10.1002/ana.26345
Abstract: The encephalitis associated with antibodies against contactin‐associated proteinlike 2 (CASPR2) is presumably antibody‐mediated, but the antibody effects and whether they cause behavioral alterations are not well known. Here, we used a mouse model of patients'… read more here.
Keywords: alter memory; antibodies reversibly; caspr2; caspr2 antibodies ... See more keywords
Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero
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DOI: 10.1007/s00401-017-1751-5
Abstract: Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recently reported a fivefold increase in CASPR2-antibodies in mid-gestation sera… read more here.
Keywords: igg exposed; caspr2 igg; persistent microglial; caspr2 ... See more keywords
Autoimmune neuromyotonia
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DOI: 10.1097/wco.0000000000001104
Abstract: Purpose of review Autoimmune neuromyotonia encompasses a group of rare immune-mediated neurological disorders frequently associated with anti-contactin-associated protein-like 2 (CASPR2) antibodies and featuring clinical and electrical signs of peripheral nerve hyperexcitability (PNH). We aim to… read more here.
Keywords: anti caspr2; autoimmune neuromyotonia; caspr2 antibodies; autoimmune ... See more keywords
Coexistence of NMDAR and CASPR2 Antibodies with HLA-B5 Positivity: A Puzzling Trilogy with Atypical Neuroimaging
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DOI: 10.4103/aian.aian_165_22
Abstract: Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 5 ¦ September-October 2022 946 Sir, Autoimmune encephalitis has recently emerged as a major cause of neurologic morbidity, significantly mediated by anti‐N‐methyl‐D‐aspartate receptor (NMDAR)… read more here.
Keywords: nmdar; neurology; nmdar caspr2; caspr2 antibodies ... See more keywords