Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2
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DOI: 10.1161/circresaha.121.320661
Abstract: Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac arrhythmia syndrome triggered by catecholamines released during exercise, stress, or sudden emotion. Variants in the calsequestrin-2 gene (CASQ2), encoding the major calcium (Ca) binding… read more here.
Keywords: dominant cpvt2; sarcoplasmic reticulum; cpvt2; autosomal dominant ... See more keywords
An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia
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DOI: 10.1161/circulationaha.120.045723
Abstract: Supplemental Digital Content is available in the text. Background: Genetic variants in calsequestrin-2 (CASQ2) cause an autosomal recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated reports have identified arrhythmic phenotypes among heterozygotes. Improved… read more here.
Keywords: international multicenter; catecholaminergic polymorphic; cpvt; inheritance ... See more keywords
Identification of Key Biomarkers in Bladder Cancer: Evidence from a Bioinformatics Analysis
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DOI: 10.3390/diagnostics10020066
Abstract: Bladder cancer (BCa) is one of the most common malignancies and has a relatively poor outcome worldwide. However, the molecular mechanisms and processes of BCa development and progression remain poorly understood. Therefore, the present study… read more here.
Keywords: bladder cancer; casq2; bca; identification key ... See more keywords