Prevention of Injury‐Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3643
Abstract: Traumatic joint injuries produce osteoarthritic cartilage manifesting accelerated chondrocyte terminal differentiation and matrix degradation via unknown cellular and molecular mechanisms. Here we report the ability of biomechanical stress to increase expression of the calcium‐sensing receptor… read more here.
Keywords: rodent temporomandibular; joint; temporomandibular joint; casr ... See more keywords
Calcium sensing receptor in developing human airway smooth muscle
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28115
Abstract: Airway smooth muscle (ASM) regulation of airway structure and contractility is critical in fetal/neonatal physiology in health and disease. Fetal lungs experience higher Ca2+ environment that may impact extracellular Ca2+ ([Ca2+]o) sensing receptor (CaSR). Well‐known… read more here.
Keywords: physiology; casr; smooth muscle; ca2 ... See more keywords
Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_41
Abstract: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that plays a key role in calcium homeostasis, by sensing free calcium levels in blood and regulating parathyroid hormone secretion in response. The CaSR is highly… read more here.
Keywords: receptor casr; casr; calcium; sensing receptor ... See more keywords
Calcium-sensing receptor: evidence and hypothesis for its role in nephrolithiasis
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1096-0
Abstract: Calcium-sensing receptor (CaSR) is a plasma-membrane G protein-coupled receptor activated by extracellular calcium and expressed in kidney tubular cells. It inhibits calcium reabsorption in the ascending limb and distal convoluted tubule when stimulated by the… read more here.
Keywords: nephrolithiasis; role; casr; calcium ... See more keywords
Hypercalcémie familiale bénigne révélée par des crises de colique néphrétique : description d’une nouvelle mutation du Calcium Sensing Receptor (CaSR)
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.352
Abstract: Introduction L’association de lithiases renales et d’hypercalcemie peut-etre un piege diagnostique, en presence d’une hypercalcemie familiale benigne, necessitant d’approfondir la mise au point au niveau phosphocalcique et genetique. Cas clinique Nous rapportons le cas d’un… read more here.
Keywords: par; nouvelle mutation; casr; calcium ... See more keywords
Dietary γ-glutamyl valine (γ-EV) ameliorates TNF-α induced vascular inflammation via endothelial calcium-sensing receptor (CaSR).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c04526
Abstract: γ-glutamyl valine (γ-EV), commonly found in edible beans, was shown to reduce gastrointestinal inflammation via activation of calcium-sensing receptor (CaSR). The present study aimed to evaluate the efficacy of γ-EV in modulating the TNF-α induced… read more here.
Keywords: receptor casr; inflammation via; casr; sensing receptor ... See more keywords
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00474-0
Abstract: The human calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca2+ homeostasis in the blood. The general consensus is that extracellular Ca2+ is the principal agonist of CaSR. Aliphatic… read more here.
Keywords: ca2 trp; casr; ca2; activation ... See more keywords
Implications of the calcium-sensing receptor in ischemia/reperfusion
Sign Up to like & getrecommendations! Published in 2017 at "Acta Cardiologica"
DOI: 10.1080/00015385.2017.1291136
Abstract: Abstract The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) which was first isolated from bovine parathyroid glands. Its complex structure has been well characterized, which helped to better understand its function. The CaSR… read more here.
Keywords: reperfusion; casr; implications calcium; receptor ... See more keywords
Role of calcium-sensing receptor in regulating spontaneous activation of postovulatory aging rat oocytes†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1093/biolre/iox178
Abstract: Abstract Mechanisms for postovulatory aging (POA) of oocytes and for spontaneous activation (SA) of rat oocytes are largely unknown. Expression of calcium-sensing receptor (CaSR) in rat oocytes and its role in POA remain unexplored. In… read more here.
Keywords: rat oocytes; casr; activation; postovulatory aging ... See more keywords
Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy263
Abstract: Abstract The calcium‐sensing receptor (CaSR) is a homodimeric G‐protein‐coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. The central importance of… read more here.
Keywords: loss gain; signalling bias; casr; calcium ... See more keywords
Identification of p.Arg205Cys in CASR in an autosomal dominant hypocalcaemia type 1 pedigree
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000026443
Abstract: Abstract Rationale: Autosomal dominant hypocalcaemia type 1 (ADH1) is a genetic disease characterized by benign hypocalcemia, inappropriately low parathyroid hormone levels and mostly hypercalciuria. It is caused by the activating mutations of the calcium-sensing receptor… read more here.
Keywords: casr; adh1; dominant hypocalcaemia; arg205cys ... See more keywords